Simultaneous Delivery of Multiple Antimicrobial Agents by Biphasic Scaffolds for Effective Treatment of Wound Biofilms
| Autor: | Yajuan Su, Jingwei Xie, Ronald R. Hollins, Alec McCarthy, Shannon L. Wong, Guangshun Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Drug media_common.quotation_subject Biomedical Engineering Pharmaceutical Science 02 engineering and technology 010402 general chemistry medicine.disease_cause 01 natural sciences Article Microbiology Biomaterials medicine Humans Effective treatment media_common Chemistry Pseudomonas aeruginosa Biofilm biochemical phenomena metabolism and nutrition 021001 nanoscience & nanotechnology Antimicrobial Anti-Bacterial Agents 0104 chemical sciences Staphylococcus aureus Biofilms Nanofiber Wound Infection Vancomycin 0210 nano-technology medicine.drug |
| Zdroj: | Adv Healthc Mater |
| ISSN: | 2192-2659 2192-2640 |
| Popis: | Biofilms pose a major challenge to control wound-associated infections. Due to biofilm impenetrability, traditional antimicrobial agents are often ineffective in combating biofilms. Herein, we reported a biphasic scaffold as an antimicrobial delivery system by integrating nanofiber mats with dissolvable microneedle arrays for the effective treatment of bacterial biofilms. Different combinations of antimicrobial agents, including AgNO(3), Ga(NO(3))(3), and vancomycin, were incorporated into nanofiber mats by co-axial electrospinning, which enabled sustained delivery of these drugs. The antimicrobial agents-incorporated dissolvable microneedle arrays allowed direct penetration of drugs into biofilms. By optimizing the administration strategies, drug combinations, and microneedle densities, biphasic scaffolds were able to eradicate both methicillin-resistant Staphylococcus aureus (MRSA) and MRSA/Pseudomonas aeruginosa blend biofilms in an ex vivo human skin wound infection model without necessitating surgical debridement. Taken together, the combinatorial system comprised of nanofiber mats and microneedle arrays can provide an efficacious delivery of multiple antimicrobial agents for the treatment of bacterial biofilms in wounds. |
| Databáze: | OpenAIRE |
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