Classical gene amplifications in human breast cancer are not associated with distant solid metastases
| Autor: | Marie-Hélène Champème, Keltouma Driouch, M. Beuzelin, Ivan Bièche, Rosette Lidereau |
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| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Receptor ErbB-2 Mammary gland Fibroblast Growth Factor 3 Genes myc Breast Neoplasms Biology Metastasis Breast cancer Proto-Oncogene Proteins Gene duplication medicine Humans Neoplasm Metastasis skin and connective tissue diseases Gene Genes mos Chromosomes Human Pair 11 Gene Amplification Cancer DNA Neoplasm Genes erbB-2 medicine.disease Fibroblast Growth Factors Pleural Effusion medicine.anatomical_structure Oncology Tumor progression Chromosomal region Cancer research Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression. Images Figure 1 |
| Databáze: | OpenAIRE |
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