The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines

Autor: Olga Karpova, Nikolai Nikitin, Anastasia A. Dmitrieva, E.K. Petrova, E.A. Trifonova
Rok vydání: 2016
Předmět:
Zdroj: Vaccine. 34:1006-1011
ISSN: 0264-410X
Popis: Rubella is a highly contagious viral disease which is mostly threatens to women of reproductive age. Existent live attenuated vaccines are effective enough, but have some drawbacks and are unusable for a certain group of people, including pregnant women and people with AIDS and other immunodeficiency. Thereby the development of alternative non-replicating, recombinant vaccines undoubtedly is needed. This review discusses the protein E1 and E2 role in formation of immune response and perspectives in development of new generation recombinant vaccines using them.
Databáze: OpenAIRE