The key role of rubella virus glycoproteins in the formation of immune response, and perspectives on their use in the development of new recombinant vaccines
| Autor: | Olga Karpova, Nikolai Nikitin, Anastasia A. Dmitrieva, E.K. Petrova, E.A. Trifonova |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
030106 microbiology Biology medicine.disease_cause Rubella Epitope Epitopes 03 medical and health sciences Immune system Viral Envelope Proteins Acquired immunodeficiency syndrome (AIDS) Pregnancy medicine Humans Rubella Vaccine Antigens Viral Immunodeficiency Vaccines Synthetic Attenuated vaccine General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Rubella virus medicine.disease Virology Recombinant Proteins 030104 developmental biology Infectious Diseases Immunology Molecular Medicine Female Viral disease |
| Zdroj: | Vaccine. 34:1006-1011 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2016.01.010 |
| Popis: | Rubella is a highly contagious viral disease which is mostly threatens to women of reproductive age. Existent live attenuated vaccines are effective enough, but have some drawbacks and are unusable for a certain group of people, including pregnant women and people with AIDS and other immunodeficiency. Thereby the development of alternative non-replicating, recombinant vaccines undoubtedly is needed. This review discusses the protein E1 and E2 role in formation of immune response and perspectives in development of new generation recombinant vaccines using them. |
| Databáze: | OpenAIRE |
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