17β-Estradiol Prevents Dysfunction of Canine Coronary Endothelium and Myocardium and Reperfusion Arrhythmias After Brief Ischemia/Reperfusion
| Autor: | M Y Farhat, Young D. Kim, David Eric Lees, Peter C. Kouretas, Adam K. Myers, George Thomas, John F. Beauregard, Barbara Chen |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Nitroprusside Endothelium Vasodilator Agents Myocardial Ischemia Ischemia Hemodynamics Myocardial Reperfusion Injury Vasodilation Anterior Descending Coronary Artery Dogs Coronary Circulation Physiology (medical) medicine Animals Endothelial dysfunction Estradiol biology business.industry Vascular disease Fissipedia Arrhythmias Cardiac Heart medicine.disease biology.organism_classification Coronary Vessels Myocardial Contraction Acetylcholine Vasomotor System medicine.anatomical_structure Anesthesia Endothelium Vascular Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 94:2901-2908 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.94.11.2901 |
| Popis: | Background Brief myocardial ischemia is associated with myocardial and coronary endothelial dysfunction caused by oxygen free radicals released during reperfusion. Estrogen, known to have antioxidant activity, may prevent these complications. Methods and Results We assessed the effect of 2 weeks of treatment with 17β-estradiol (E, 100 μg·kg −1 ·d −1 , n=12) or placebo (P, n=15) on myocardial and coronary endothelial function during the first 2 hours of reperfusion in dogs subjected to 15 minutes of ischemia induced by occlusion of the left anterior descending coronary artery (LAD). Our results show that the incidence of ventricular arrhythmias significantly decreased in E (3 of 12) compared with P (11 of 15). Systolic shortening, significantly depressed in P during early reperfusion, was maintained at preischemic levels in E. During reperfusion, the increase in LAD flow to acetylcholine, attenuated in P (60±6%), was preserved in E (151±28%) and was associated with increased serum nitrite/nitrate concentration. n -Pentane in exhaled gas in vivo, an index of lipid peroxidation, increased significantly during early reperfusion in P (from 9.1±1.9 to 41.6±13.0 ppb, P P Conclusions Estrogen protects against endothelial and myocardial dysfunction resulting from brief ischemia/reperfusion. This protection may relate to an antioxidant effect of estrogen. |
| Databáze: | OpenAIRE |
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