Exercise stress testing in healthy subjects during cholinergic stimulation after a single dose of pyridostigmine
| Autor: | Ricardo Vivacqua Cardoso Costa, Salvador Manoel Serra, Sergio Henrique Rodolpho Ramalho, Antonio Claudio Lucas da Nóbrega, Kelb Bousquet Santos, Bianca Gouvêa Bastos |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male lcsh:Diseases of the circulatory (Cardiovascular) system exercise stress testing Oxygen pulse Hemodynamics Blood Pressure Oxygen Consumption Double-Blind Method Heart Rate Heart rate Humans Medicine Cross-Over Studies business.industry autonomic nervous system Cardiorespiratory fitness Blood pressure Pyridostigmine lcsh:RC666-701 pyridostigmine Anesthesia Exercise Test Breathing Female Cholinesterase Inhibitors Cardiology and Cardiovascular Medicine business Respiratory minute volume Pyridostigmine Bromide medicine.drug |
| Zdroj: | Arquivos Brasileiros de Cardiologia, Volume: 76, Issue: 4, Pages: 279-284, Published: APR 2001 Arquivos Brasileiros de Cardiologia, Vol 76, Iss 4, Pp 279-284 (2001) Arquivos Brasileiros de Cardiologia v.76 n.4 2001 Arquivos Brasileiros de Cardiologia Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
| ISSN: | 0066-782X |
| DOI: | 10.1590/s0066-782x2001000400002 |
| Popis: | OBJETIVE: The evaluation, by exercise stress testing, of the cardiorespiratory effects of pyridostigmine (PYR), a reversible acetylcholinesterase inhibitor. METHODS: A double-blind, randomized, cross-over, placebo-controlled comparison of hemodynamic and ventilation variables of 10 healthy subjects who underwent three exercise stress tests (the first for adaptation and determination of tolerance to exercise, the other two after administration of placebo or 45mg of PYR). RESULTS: Heart rate at rest was: 68±3 vs 68±3bpm before and after placebo, respectively (P=0.38); 70±2 vs 59±2bpm, before and after pyridostigmine, respectively (P |
| Databáze: | OpenAIRE |
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