Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for the treatment of endometrial cancer with peritoneal carcinomatosis
| Autor: | Jean Marc Bereder, Delphine Quaranta, Mariangela Desantis, Jérôme Delotte, M. Frigenza, André Bongain, Daniel Benchimol |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Disease-Free Survival Cohort Studies Antineoplastic Combined Chemotherapy Protocols medicine Humans Infusions Parenteral Prospective Studies Lost to follow-up Peritoneal Neoplasms Aged Cisplatin business.industry Endometrial cancer Carcinoma Obstetrics and Gynecology Hyperthermia Induced Middle Aged medicine.disease Combined Modality Therapy Endometrial Neoplasms Surgery Peritoneal carcinomatosis Clinical trial Reproductive Medicine Doxorubicin Conventional PCI Peritoneal Cancer Index Female Hyperthermic intraperitoneal chemotherapy Peritoneum business medicine.drug |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 172:111-114 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2013.10.026 |
| Popis: | Objective To investigate the benefit of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of endometrial peritoneal carcinomatosis. Study design Preoperative, intraoperative and postoperative data were collected prospectively for 13 patients treated in our University hospital. Results Of the thirteen patients treated, one patient was lost to follow up. Three patients died within the first twelve months of treatment, and two patients died at respectively 12.4 and 19.4 months after the HIPEC procedure. Seven patients are alive, four of them without recurrence, between 1.5 and 124.8 months after surgery. The Peritoneal Cancer Index (PCI) and the Completeness of Cytoreduction-Score (CC-S) are prognostic factors for survival after HIPEC treatment for peritoneal carcinomatosis of endometrial origin. Conclusions The significant survival time in selected patients should lead to a study of the management of peritoneal carcinomatosis of endometrial origin in a larger number of cases, and justifies a clinical trial on a larger scale. |
| Databáze: | OpenAIRE |
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