An Open, Controlled, Randomized Comparison of Cyclosporine and Azathioprine in the Treatment of Rheumatoid Arthritis: A Preliminary Report
| Autor: | Christian F. Salvesen, Erik Kåss, Ove J. Mellbye, Hans Erik Rugstad, Gunnar Saelid, Knut J. Berg, Øystein Førre, Frithjof Bjerkhoel |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Immunology Cyclosporins Pilot Projects Azathioprine law.invention Arthritis Rheumatoid Random Allocation Grip strength Rheumatology Randomized controlled trial Preliminary report law medicine Humans Immunology and Allergy Pharmacology (medical) Chemotherapy business.industry medicine.disease Surgery Ritchie articular index Rheumatoid arthritis Interphalangeal Joint business medicine.drug |
| Zdroj: | Arthritis & Rheumatism. 30:88-92 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.1780300112 |
| Popis: | Cyclosporine (10 mg/kg/day) and azathioprine (2.5-3 mg/kg/day) were compared for 26 weeks in an open, controlled, randomized study of 24 patients with rheumatoid arthritis. Each treatment group consisted of 12 patients. Those patients who took cyclosporine improved significantly in the 50-foot walk time, circumferences of proximal interphalangeal joints, Ritchie articular index, global assessment by investigator, and grip strength, when compared with baseline findings. In the azathioprine group, there was improvement only in grip strength. |
| Databáze: | OpenAIRE |
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