The psychopharmacology of tachykinin NK-3 receptors in laboratory animals
| Autor: | Maurizio Massi, Giuseppe de Caro, Izabela Panocka |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Drugs of abuse
Alcohol Drinking Physiology medicine.drug_class Pharmacology Biochemistry Mice Cellular and Molecular Neuroscience Endocrinology medicine Animals Hypoxia Receptor Neurotransmitter Agents Brain Receptors Neurokinin-3 Receptor antagonist Antidepressive Agents Conditioned place preference Rats Anti-Anxiety Agents Anxiogenic Anxiety Alcohol intake Psychopharmacology medicine.symptom Psychology |
| Zdroj: | Peptides. 21:1597-1609 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(00)00291-6 |
| Popis: | The present article reviews the studies so far published on the psychopharmacological effects mediated by tachykinin NK-3 receptors in laboratory animals. Central administration of NK-3 receptor agonists has been reported to attenuate alcohol intake in alcohol-preferring rats and to evoke conditioned place preference. These findings suggest that NK-3 receptors may affect reward processes to drugs of abuse. Anxiolytic-like and antidepressant-like effects have been previously reported for NK-1 receptor antagonists, and anxiolytic-like effects for NK-2 receptor antagonists. More recently, it has been shown that NK-3 receptor agonists have anxiolytic-like and antidepressant-like effects in mice and rats, while an NK-3 receptor antagonist was reported to be anxiogenic in mice. These findings indicate that different TK receptor subtypes may be involved in anxiolytic-like and antidepressant-like effects in laboratory animals and raise interest for the possible role of NK-3 receptors in the control of anxiety and depression in man. |
| Databáze: | OpenAIRE |
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