Effect of levofloxacin treatment on semen hyperviscosity in chronic bacterial prostatitis patients
| Autor: | Beatrice Ornella Vicari, Enzo Vicari, M. C. Mazzarino, Michele Salemi, L. O. Vicari, Roberto Castiglione |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.drug_class Urology Antibiotics Prostatitis Semen male infertility Male infertility Andrology Chronic bacterial prostatitis levofloxacin reactive oxygen species semen cytokines semen quantitative hyperviscosity 03 medical and health sciences Leukocyte Count Young Adult 0302 clinical medicine Endocrinology Levofloxacin medicine Humans Chlamydia Sperm motility Infertility Male 030219 obstetrics & reproductive medicine business.industry Interleukin-6 Tumor Necrosis Factor-alpha Viscosity General Medicine Bacterial Infections medicine.disease Sperm Anti-Bacterial Agents 030104 developmental biology Treatment Outcome Italy Chronic Disease Sperm Motility business medicine.drug |
| Popis: | Changes in seminal fluid viscosity (SFV), reactive oxygen species (ROS) production, cytokines and seminal leucocyte concentration related to microbiological outcome in patients with chronic bacterial prostatitis (CBP) were studied. One hundred and ten infertile patients with CBP (positive sperm culture ≥10(5) colony-forming units [CFU] ml(-1), pathogens or Chlamydia in expressed prostatic secretions) were treated with levofloxacin 500 mg daily for 14 consecutive days per month for 3 months. In case of bacterial prostatitis, two conditions were examined: responders, eradication of 0 to10(3) CFU ml(-1) (n = 78) and poor responders,10(3) to10(5) CFU ml(-1) (n = 32). Compared with poor responders, responders showed a significant increase of sperm progressive motility and a significant decrease in seminal leucocyte count, SFV, liquefaction time, ROS production (in all fractions and conditions), seminal tumour necrosis factor-α and interleukin 6. None of these variables showed significant differences compared with a control group of 37 fertile men. On the other hand, the poor responders showed significant changes in these variables compared with matched pretreatment values. In patients with CBP, antibiotic therapy alone leads to eradication in ≈71%, with improvement of sperm progressive motility, SFV and the framework of prooxidative factors. However, in the remaining ≈29% with poor antibiotic responsiveness, a deterioration of all variables is observed. |
| Databáze: | OpenAIRE |
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