Long non-coding RNA activated by TGF-β expression in cancer prognosis: A meta-analysis
| Autor: | Longzhen Piao, Yuzhen Cui, Songnan Zhang, Xianglan Quan, Hong-Hua Sun, Xionghu Shen, Yan Cui |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Cochrane Library Cancer prognosis 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Internal medicine Neoplasms medicine Humans biology business.industry RNA Cancer General Medicine Transforming growth factor beta medicine.disease Prognosis Long non-coding RNA 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Lymphatic Metastasis biology.protein Surgery Female RNA Long Noncoding business Transforming growth factor |
| Zdroj: | International journal of surgery (London, England). 58 |
| ISSN: | 1743-9159 |
| Popis: | Recently, long non-coding RNA activated by transforming growth factor beta (TGF-β) (lncRNA ATB) was shown to be useful in cancer prognosis, however, its prognostic value in human cancer has been inconsistent. Our study aimed to explore the prognostic role of lncRNA ATB expression in cancer prognosis.PubMed, Embase, and Cochrane Library databases were thoroughly searched to retrieve studies focusing on the prognostic role of lncRNA ATB expression in cancer, and meta-analysis was performed.A total of 15 studies were included into this meta-analysis. High lncRNA ATB expression was significantly related to shorter overall survival (OS) (HR = 2.44, 95%CI = 1.98-3.01, P 0.01), recurrence-free survival (RFS) (HR = 1.85, 95%CI = 1.42-2.40, P 0.01), disease-free survival (DFS) (HR = 3.61, 95%CI = 2.45-5.33, P 0.01), and progression-free survival (PFS) (HR = 2.97, 95%CI = 2.12-4.16, P 0.01) when compared with low lncRNA ATB expression in cancer. Moreover, Patients with high lncRNA ATB expression tended to have worse tumor differentiation (P 0.01), more advanced clinical stage (P 0.01), deeper tumor invasion (P 0.01), earlier distant metastases (P = 0.02), lymph node metastases (P = 0.04), and vascular invasion (P 0.01) when compared with those with low lncRNA ATB expression.High lncRNA ATB expression was significantly associated with worse prognosis in cancer. LncRNA ATB expression could be used as a prognostic biomarker for human cancer. |
| Databáze: | OpenAIRE |
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