Late postpoliomyelitis muscular atrophy: clinical, virologic, and immunologic studies
| Autor: | Aurelia Krezlewicz, David L. Madden, Marinos C. Dalakas, Nicholas M. Papadopoulos, John L. Sever, Isabel C. Shekarchi, Paul Albrecht |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Biopsy Antibodies Viral Gastroenterology Cachexia Fasciculation Post-polio syndrome Internal medicine medicine Humans Amyotrophic lateral sclerosis Wasting Aged business.industry Muscles Muscle weakness Middle Aged medicine.disease Poliomyelitis Postpoliomyelitis Syndrome Muscular Atrophy Poliovirus Infectious Diseases Immunology Female medicine.symptom business |
| Zdroj: | Reviews of infectious diseases. 6 |
| ISSN: | 0162-0886 |
| Popis: | Seventeen relatively young patients, ages 31-65 years (average, 45) with prior poliomyelitis, who after a number of years of stability had experienced new neuromuscular symptoms, were studied. Seven patients had deterioration of functional capacity and then stabilization without new muscular weakness. The other 10 had late postpoliomyelitis muscular atrophy (late PPMA) characterized by focal progressive muscle weakness, wasting, fasciculations, and muscle pains affecting previously spared muscles or muscles previously affected but recovered. Four patients with late PPMA had lymphorrhages or lymphocytic infiltrates in their biopsied muscle; three of three patients had oligoclonal IgG bands in their spinal fluid, and five had variable peripheral T lymphocyte-subset ratios. In one patient with late PPMA, antibodies to poliovirus were specifically elevated in the cerebrospinal fluid. Our findings indicate that new motor-neuron disease can occur in patients with prior poliomyelitis and that immunopathologic mechanisms may play a role. Some patients with a history of acute paralytic poliomyelitis experience not only residual muscle weakness from the initial illness, but they also develop new neuromuscular symptoms later in life. These symptoms may vary in form and severity from simple decline of musculoskeletal function to the development of new progressive muscle weakness and typical cases of amyotrophic lateral sclerosis [1-7]. The cause and frequency of these symptoms are unknown. Some of the proposed explanations include reactivation of poliovirus and normal aging process in previously affected muscle groups collaterally innervated by an already de |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|