Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties
| Autor: | Mathurin Grogna, Rudi Cloots, André Luxen, Christophe Detrembleur, Jean-François Desreux, Catherine Passirani, Christine Jérôme, Nolwenn Lautram |
|---|---|
| Přispěvatelé: | Laboratoire de Spectroscopie d'Electrons Diffusés, Université de Liège, Laboratoire de Chimie Inorganique Structurale, Cyclotron Research Centre, Center for Education and Research on Macromolecules, Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Centre d'Etude et de Recherche sur les Macromolécules (CERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Relaxometry
Polymers and Plastics Gadolinium media_common.quotation_subject [SDV]Life Sciences [q-bio] chemistry.chemical_element Bioengineering 02 engineering and technology macromolecular substances 010402 general chemistry 01 natural sciences Biochemistry Micelle chemistry.chemical_compound Nuclear magnetic resonance Contrast (vision) media_common chemistry.chemical_classification Ethylene oxide Organic Chemistry technology industry and agriculture Polymer 021001 nanoscience & nanotechnology Grafting 3. Good health 0104 chemical sciences chemistry Design synthesis 0210 nano-technology |
| Zdroj: | Polymer Chemistry Polymer Chemistry, Royal Society of Chemistry-RSC, 2010, 1, pp.1485-90 |
| ISSN: | 1759-9954 1759-9962 |
| Popis: | International audience; New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents. |
| Databáze: | OpenAIRE |
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