Differences in the magnetic resonance imaging parameter T2* may be identified during the course of canine patellar tendon healing: a pilot study
| Autor: | Kei Hayashi, Matthew F. Koff, Kathleen N. Meyers, Ryan Breighner, Hollis G. Potter, Brian G. Caserto, Bin Q. Lin, Sarah L. Pownder |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
medicine.diagnostic_test business.industry medicine.medical_treatment Failure strain Magnetic resonance imaging Strain (injury) medicine.disease musculoskeletal system Patellar tendon 030218 nuclear medicine & medical imaging Tendon 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Radiology Nuclear Medicine and imaging Original Article business Large diameter Nuclear medicine Tendon healing 030217 neurology & neurosurgery Reduction (orthopedic surgery) |
| Zdroj: | Quant Imaging Med Surg |
| Popis: | BACKGROUND: Previous studies have utilized ultrashort echo (UTE) magnetic resonance imaging (MRI), and derived T2* maps, to evaluate structures with highly ordered collagen structures such as tendon. T2* maps may provide a noninvasive means to assess tendon damage and healing. This pilot study evaluated the longitudinal relationship of an induced mechanical strain on the patellar tendon with corresponding UTE T2* metrics, histologic and biomechanical evaluation at two post-operative time points. METHODS: A total of 27 patellar tendons in male Beagles were surgically subjected to stretching by a small diameter (SmD) or a large diameter (LgD) diameter rod to induce damage due to strain, and evaluated at 4- and 8-week intervals using quantitative MRI (qMRI), biomechanical testing, and histology. A separate set of 16 limbs were used as controls. RESULTS: The tendons experienced a 67% and 17% prolongation of short T2* values as compared to controls at 4 and 8 weeks post-operatively, respectively. Histologic analysis displayed a trend of increased collagen disruption at 4 weeks followed by presence of greater organization at 8 weeks. Biomechanical evaluation found a reduction of tendon modulus and failure strain at both time points, and an increase in cross-sectional area at 4 weeks as compared to controls. CONCLUSIONS: These findings display tendon healing in response to an imposed strain and present the utility of qMRI to evaluate longitudinal differences of patellar tendon T2* values in a model of induced subclinical tendon damage. The qMRI technique of UTE provides a means to non-invasively evaluate the healing process of a mechanically damaged tendon. |
| Databáze: | OpenAIRE |
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