Salivary Cortisol Day Curves in Addison’s Disease in Patients on Hydrocortisone Replacement
| Autor: | Naomi S. Levitt, Desmond A. Schatz, Tahir S Pillay, Gudmundur Johannsson, David Haarburger, Ian L. Ross, J. S. Van der Walt |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Saliva Hydrocortisone Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Young Adult Endocrinology Addison Disease Pharmacokinetics Internal medicine Confidence Intervals medicine Humans In patient Adrenocortical Insufficiency Salivary cortisol Dose-Response Relationship Drug business.industry Biochemistry (medical) Area under the curve General Medicine Middle Aged medicine.disease Area Under Curve Case-Control Studies Addison's disease Female business medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 45:62-68 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-0032-1321855 |
| Popis: | Using salivary cortisol (SC) measurements, cortisol exposure in Addison's disease patients on hydrocortisone replacement was determined and compared with healthy controls. Cortisol pharmacokinetics was assessed in 31 patients with Addison's disease on replacement hydrocortisone doses (median daily dose 20 mg; range 5-50 mg) and 30 healthy control subjects. Saliva samples (n=16) were collected between 08:00 and 00:00 h in 1 day, using a passive drool technique. Cortisol exposure was evaluated by noncompartmental approach. In the patients, cortisol exposure was significantly higher than in controls: median inter-quartile range (IQR) peak cortisol (C(max)) 174.5 (59.3-837.0) vs. 6.50 (4.7-19.3) nmol/l, p=0.0001; area under the curve (AUC) 390.1 (177.1-928.9) vs. 21.4 (14.6-28.4) minutes*nmol/l, p=0.0001, trough cortisol level (C(min)) 0.49 (0.49-0.96) vs. 0.49 (0.49-0.49) nmol/l, p=0.02, occurring at 480.0 (0.1-660.0) vs. 405.0 (180.0-570.0) min, p=0.56. First peak cortisol was 174.5 (53.0-754.7) vs. 6.27 (3.90-8.47) nmol/l, p=0.0001 and second peak cortisol 18.90 (5.22-76.9) vs. 3.12 (1.76-4.79) nmol/l, p=0.0001. The time to first peak cortisol differed between the 2 groups, 30 (30-75) vs. 0.1 (0.1-30) minutes; p=0.0001. At doses studied, hydrocortisone replacement therapy results in cortisol pharmacokinetics being markedly different from endogenous cortisol profiles in healthy control subjects. Addison's disease patients had significantly higher SC levels compared to healthy control subjects. |
| Databáze: | OpenAIRE |
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