Experimental intermittent ischemia augments exercise-induced inflammatory cytokine production
| Autor: | Jonathan R. Murrow, Nathan T. Jenkins, Jarrod A. Call, Daniel D. Shill, Kristine R. Polley, T. Bradley Willingham, Kevin K. McCully |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology medicine.medical_treatment Ischemia Inflammation Isometric exercise 030204 cardiovascular system & hematology Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endurance training Isometric Contraction Physiology (medical) Internal medicine Humans Medicine Muscle Skeletal Interleukin 6 Exercise biology Interleukin-6 Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factors business.industry Interleukin-8 030229 sport sciences medicine.disease Interleukin-10 Surgery Fibroblast Growth Factors Vascular endothelial growth factor Forearm Interleukin 10 Cytokine chemistry Cardiovascular Diseases Cardiology biology.protein Cytokines medicine.symptom business |
| Zdroj: | Journal of Applied Physiology. 123:434-441 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.01006.2016 |
| Popis: | Acute exercise-induced inflammation is implicated in mediating the beneficial adaptations to regular exercise. Evidence suggests that reduced oxygen and/or blood flow to contracting muscle alters cytokine appearance. However, the acute inflammatory responses to hypoxic/ischemic exercise have been documented with inconsistent results and may not accurately reflect the ischemia produced during exercise in patients with ischemic cardiovascular diseases. Therefore, we determined the extent to which local inflammation is involved in the response to ischemic exercise. Fourteen healthy males performed unilateral isometric forearm contractions for 30 min with and without experimental ischemia. Blood was drawn at baseline, 5 and 10 min into exercise, at the end of exercise, and 30, 60, and 120 min after exercise. Oxygen saturation levels, as measured by near-infrared spectroscopy, were reduced by 10% and 41% during nonischemic and ischemic exercise, respectively. Nonischemic exercise did not affect cytokine values. Ischemia enhanced concentrations of basic fibroblast growth factor, interleukin (IL)-6, IL-10, tumor necrosis factor-alpha, and vascular endothelial growth factor during exercise, but IL-8 was not influenced by ischemic exercise. In conclusion, the present study demonstrates that ischemic, small-muscle endurance exercise elicits local inflammatory cytokine production compared with nonischemic exercise. NEW & NOTEWORTHY We demonstrate that ischemic, small-muscle endurance exercise elicits local inflammatory cytokine production compared with nonischemic exercise. The present study advances our knowledge of the inflammatory response to exercise in a partial ischemic state, which may be relevant for understanding the therapeutic effects of exercise training for people with ischemic cardiovascular disease-associated comorbidities. |
| Databáze: | OpenAIRE |
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