Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase
| Autor: | Andrea Bolognesi, Letizia Polito, Maria Giulia Battelli, Massimo Bortolotti |
|---|---|
| Přispěvatelé: | Battelli, Maria Giulia, Bortolotti, Massimo, Polito, Letizia, Bolognesi, Andrea |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Xanthine Dehydrogenase Clinical Biochemistry Review Article Pharmacology TGF-β transforming growth factor-beta medicine.disease_cause TNF-α tumor necrosis factor-α Biochemistry Cancer risk chemistry.chemical_compound 0302 clinical medicine NAD nicotinamide adenine dinucleotide LDL low-density lipoprotein Neoplasms Hyperuricemia IL-6 interleukin-6 lcsh:QH301-705.5 lcsh:R5-920 Oncogenesi NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells FAD flavin adenine dinucleotide VEGF vascular endothelial growth factor Metabolic syndrome XOR xanthine oxidoreductase Cell Transformation Neoplastic COX-2 cyclooxygenase-2 Disease Progression EMT epithelial-mesenchymal transition lcsh:Medicine (General) Xanthine oxidoreductase HDL high-density lipoprotein IGF-1 insulin-like growth factor-1 MMP matrix metalloproteases Risk Assessment HIF-1α hypoxia-inducible factor-1-alpha Moco molybdopterin cofactor RNS reactive nitrogen species 03 medical and health sciences ROS reactive oxygen species Insulin resistance Diabetes mellitus medicine Animals Humans Oncogenesis Inflammation NO nitric oxide XO xanthine oxidase PPARs peroxisome proliferator-activated receptors business.industry Organic Chemistry Cancer medicine.disease XDH xanthine dehydrogenase Enzyme Activation 030104 developmental biology chemistry lcsh:Biology (General) Oxidative stress Oxidative stre Uric acid business 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Redox Biology, Vol 21, Iss, Pp-(2019) Redox Biology |
| ISSN: | 2213-2317 |
| Popis: | Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders. XOR can play a role in the pathogenesis of both metabolic syndrome and cancer through the inflammatory response and the oxidative stress elicited by the products of its activity. The reactive oxygen and nitrogen species and the uric acid derived from XOR concur to the development of hypertension, dyslipidemia and insulin resistance and participate in both cell transformation and proliferation, as well as in the progression and metastasis process. Despite the availability of different drugs to inhibit in vivo XOR activity, the complexity of XOR inhibition effects should be carefully considered before clinical application, save in the case of symptomatic hyperuricemia. Graphical abstract fx1 Highlights • Metabolic syndrome (MS) increases the risk of cancer development. • Xanthine oxidoreductase (XOR) plays a role in both MS and cancer. • Uric acid, ROS and RNS produced by XOR cause inflammation and oxidative stress. • Inflammation and oxidative stress contribute to the pathogenesis of MS and cancer. • XOR activity can be pharmacologically controlled. |
| Databáze: | OpenAIRE |
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