Frailty Can Predict Prognosis After Hepatectomy in Patients With Colorectal Liver Metastasis
| Autor: | Tetsuya Ikemoto, Shinichiro Yamada, Yu Saito, Mitsuo Shimada, Yuji Morine, Kazunori Tokuda, Masaaki Nishi, Katsuki Miyazaki |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research Prognostic factor medicine.medical_specialty Multivariate analysis Colorectal cancer medicine.medical_treatment Gastroenterology Metastasis Drug Therapy Internal medicine Overall survival Hepatectomy Humans Medicine In patient Aged Retrospective Studies Aged 80 and over Chemotherapy Frailty business.industry Liver Neoplasms General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Treatment Outcome Oncology Multivariate Analysis Female Neoplasm Recurrence Local Colorectal Neoplasms business |
| Zdroj: | Anticancer Research. 41:4637-4644 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim The aim of this study was to investigate frailty as a prognostic factor in patients with colorectal liver metastasis undergoing hepatectomy. Patients and methods Eighty-seven patients who underwent hepatectomy at our institution were enrolled. Frailty was defined as a score of ≥4 on a clinical frailty scale. Patients were divided into frailty (n=29) and non-frailty (n=58) groups. Results Overall and cancer-specific survival rates were significantly worse in the frailty group compared with the non-frailty group, and multivariate analysis revealed frailty as an independent prognostic factor. Disease-free survival tended to be worse in the frailty group. Fifty-eight patients relapsed after the first hepatectomy. Twenty-one of 58 recurrent patients were allocated to the frailty group. After recurrence, chemotherapy was significantly more frequently performed in the non-frailty group compared with the frailty group. Conclusion Frailty can predict the prognosis of patients with colorectal liver metastasis undergoing hepatectomy. |
| Databáze: | OpenAIRE |
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