Oral acyclovir and herpes labialis: a randomized, double-blind, placebo-controlled study
| Autor: | William T. McGaw, Sheri M. Samuels, G. Wayne Raborn, Michael Grace, L. David Tyrrell |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Placebo-controlled study Acyclovir Administration Oral Placebo Gastroenterology Loading dose Drug Administration Schedule law.invention Double blind Lesion Random Allocation Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans General Dentistry Herpes Labialis Clinical Trials as Topic business.industry Middle Aged Clinical trial Anesthesia Patient Compliance Female medicine.symptom business |
| Zdroj: | The Journal of the American Dental Association. 115:38-42 |
| ISSN: | 0002-8177 |
| DOI: | 10.14219/jada.archive.1987.0211 |
| Popis: | A study of the effects of oral acyclovir (200 mg), administered five times per day for 5 days in 210 patients who cultured positive for herpes labialis, is made. A total of 149 patients were followed through three episodes each of herpes labialis while taking a placebo or acyclovir. Patients were evaluated for several clinical parameters, including the loss of lesion crust and reduction of the size of the area of the lesion between day 1 and day 5. Acyclovir showed a significant antiviral effect. Results show that oral acyclovir can favorably affect some parameters, but that higher doses or a "loading dose" could improve its efficacy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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