Reduced Interhemispheric Coherence after Cerebellar Vermis Output Perturbation
| Autor: | Carmen-Denise-Mihaela Zahiu, Ioana Antoaneta Georgescu, Ana-Maria Zagrean, Stefan-Alexandru Tirlea, Elena Laura Georgescu Margarint, Leon Zagrean, Alexandru Răzvan Șteopoaie, Daniela Popa |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
kainate
Cerebellum mice cerebellum Kainate receptor Article lcsh:RC321-571 compensation motor cortex medicine interhemispheric coherence lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Dystonia business.industry General Neuroscience Glutamate receptor oscillation medicine.disease Motor coordination medicine.anatomical_structure Cerebellar vermis dystonia Motor learning business Neuroscience Motor cortex |
| Zdroj: | Brain Sciences Brain Sciences; Volume 10; Issue 9; Pages: 621 Brain Sciences, Vol 10, Iss 621, p 621 (2020) |
| ISSN: | 2076-3425 |
| Popis: | Motor coordination and motor learning are well-known roles of the cerebellum. Recent evidence also supports the contribution of the cerebellum to the oscillatory activity of brain networks involved in a wide range of disorders. Kainate, a potent analog of the excitatory neurotransmitter glutamate, can be used to induce dystonia, a neurological movement disorder syndrome consisting of sustained or repetitive involuntary muscle contractions, when applied on the surface of the cerebellum. This research aims to study the interhemispheric cortical communication between the primary motor cortices after repeated kainate application on cerebellar vermis for five consecutive days, in mice. We recorded left and right primary motor cortices electrocorticograms and neck muscle electromyograms, and quantified the motor behavior abnormalities. The results indicated a reduced coherence between left and right motor cortices in low-frequency bands. In addition, we observed a phenomenon of long-lasting adaptation with a modification of the baseline interhemispheric coherence. Our research provides evidence that the cerebellum can control the flow of information along the cerebello-thalamo-cortical neural pathways and can influence interhemispheric communication. This phenomenon could function as a compensatory mechanism for impaired regional networks. |
| Databáze: | OpenAIRE |
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