Hypoglycaemic, hypolipidaemic and antioxidant effects of blackberry beverage consumption in streptozotocin-induced diabetic rats
| Autor: | Karine Portet, Alain Michel, Ana Mercedes Pérez, Laura López Navarro, Silvia Quesada, Fabrice Vaillant, Patrick Poucheret, Olman Hidalgo, Gabriela Azofeifa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
L51 - Physiologie animale - Nutrition
0301 basic medicine Dyslipidaemia Antioxidant medicine.medical_treatment Lipid peroxidation Medicine (miscellaneous) Pharmacology medicine.disease_cause Rubus adenotrichos 03 medical and health sciences chemistry.chemical_compound Diabetes mellitus Blackberry juice medicine TX341-641 Q04 - Composition des produits alimentaires 030109 nutrition & dietetics Nutrition and Dietetics biology Nutrition. Foods and food supply Cholesterol L70 - Sciences et hygiène vétérinaires - Considérations générales Metabolism Streptozotocin medicine.disease 030104 developmental biology chemistry Biochemistry Plasma antioxidant capacity Catalase biology.protein Oxidative stress Food Science medicine.drug |
| Zdroj: | Journal of Functional Foods Journal of Functional Foods, Volumen 26. 2016 Kérwá Universidad de Costa Rica instacron:UCR Journal of Functional Foods, Vol 26, Iss, Pp 330-337 (2016) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2016.08.007 |
| Popis: | Abnormal glucose metabolism, hyperlipidaemia profiles and high levels of radical oxygen species (ROS) are classic features of diabetes. This study evaluates the effect of the consumption of two different blackberry beverages at 25 and 12.5% given orally for 40 days to rats with streptozotocin induced diabetes. The lower dose of blackberry (12.5%) non-statistically decreased glycaemia (−10.4%), triacylglycerols (−4.6%) and cholesterol (−21.0%). These differences were not statistically significant. The higher dose of blackberry (25%) significantly decreased glucose (−48.6%), triacylglycerols (−43.5%) and cholesterol (−28.6%). The higher dose of blackberry (25%) improved plasma antioxidant capacity, reduced the levels of lipid peroxidation in plasma (−19%) and in kidney (−23%). Blackberry intake did not improve catalase, suggesting that attenuation of oxidative stress via scavenging activities rather than improving the activities of antioxidant enzymes. These results provide promising data for this blackberry as a dietary adjuvant to the pharmacological management of diabetes. Consejo Nacional de Rectores/[801-B1-655]/CONARE/Costa Rica UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro Nacional de Ciencia y Tecnología de Alimentos (CITA) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect