High-dose prednisolone and bolus cyclophosphamide in interstitial lung disease associated with systemic sclerosis: a prospective open study
| Autor: | Bettadpura Shamanna Suryanaryana, Aman Sharma, Ajay Wanchu, Shefali Khanna Sharma, Pradeep Bambery |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Cyclophosphamide Prednisolone Vital Capacity Gastroenterology Bolus (medicine) Rheumatology Internal medicine medicine Humans In patient Prospective Studies Prospective cohort study Glucocorticoids Carbon Monoxide Scleroderma Systemic Dose-Response Relationship Drug business.industry Interstitial lung disease Middle Aged respiratory system medicine.disease respiratory tract diseases Surgery Open study Clinical trial Treatment Outcome Pulse Therapy Drug Female Lung Diseases Interstitial business Immunosuppressive Agents medicine.drug |
| Zdroj: | International Journal of Rheumatic Diseases. 12:239-242 |
| ISSN: | 1756-185X 1756-1841 |
| Popis: | Currently, therapy for interstitial lung disease in patients with systemic sclerosis is unsatisfactory. A prospective open label study was conducted in a North Indian tertiary Institute to assess the efficacy of intermittent pulse cyclophosphamide (CYC) and high-dose prednisolone in systemic sclerosis (SSc)-related interstitial lung disease (ILD).Consecutive patients with SSc and ILD, diagnosed on spirometry, carbon monoxide diffusing capacity (DLCO) and high-resolution computed tomography (HRCT) scan were treated. Pulmonary function tests were carried out at baseline and after 6 months. Patients received oral prednisolone 1 mg/kg body weight initially, with tapering to a dose of 7.5 mg/day was reached. Monthly CYC pulses were given for 6 months followed by 3-monthly maintenance pulses. CYC was discontinued in patients with declining pulmonary function, adverse effects or static disease after 6 months.Average disease duration of 36 patients was 59.78 +/- 63.22 months. Seven patients improved (forced vital capacity [FVC] increase 10% or DLCO increase 15%), five deteriorated (FVC decline 10% or DLCO decline 15%) and 24 had stable disease. Thus, 31 out of 36 patients either improved or had static lung disease. Mean FVC (% of predicted) improved by 4.16% over 6 months (P = 0.069). Mean DLCO (% of predicted) improved by 5.66% (P = 0.27). Average % of predicted DLCO at baseline was 39%.High-dose prednisolone with pulse CYC can either improve or stabilize lung functions in patients with severe systemic sclerosis lung disease irrespective of presence of ground glass appearance on HRCT. |
| Databáze: | OpenAIRE |
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