The effect of etodolac on bile salt and histamine-mediated gastric mucosal injury in the rat
| Autor: | Omar M. E. Abdel Salam, Siham M. El-Shenawy, Gyula Mózsik, Mahmoud S. Arbid, Seham El-Batran |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Taurocholic Acid medicine.medical_specialty Cholagogues and Choleretics Sodium medicine.medical_treatment chemistry.chemical_element Endogeny Pharmacology Gastroenterology Urethane Gastric Acid Rats Sprague-Dawley chemistry.chemical_compound Physiology (medical) Internal medicine medicine Animals Secretion Anesthesia Cyclooxygenase Inhibitors Etodolac Saline biology Chemistry General Neuroscience digestive oral and skin physiology digestive system diseases Rats Mucus Gastric Mucosa biology.protein Gastric acid Female Cyclooxygenase Histamine medicine.drug |
| Zdroj: | Journal of physiology, Paris. 95(1-6) |
| ISSN: | 0928-4257 |
| Popis: | The effect of the selective cyclo-oxygenase-type-2 (COX-2) inhibitor etodolac on gastric mucosal integrity and gastric acid secretion was investigated in the rat. Etodolac was given in doses comparable with those being used in man for therapy of rheumatic conditions. The effect of etodolac was studied in the presence of a mild barrier breaker and in the presence of increased rates of endogenous acid secretion. In conscious pylorus-ligated rats, etodolac given intragastrically in 16 or 32 mg /kg for 3 h did not by itself give rise to visible gastric mucosal injury. Etodolac, however, exacerbated gastric mucosal injury evoked by intragastric application of acidified sodium taurocholate (5 mM in 150 mM HCl) in a dose-dependent manner. This effect of edotolac was independent of changes in gastric acid secretory responses. In rats whose gastric acid secretion was stimulated by intraperitoneal histamine (5 mg/kg), and etodolac (given i.g. in doses of 16 or 32 mg/kg) also increased gastric mucosal injury caused by histamine dose-dependently in the 3-h pylorus-ligated rats. Etodolac decreased gastric mucus in the saline- and in the sodium taurocholate-treated rats. In urethane-anaesthetized acute gastric fistula rats, intragastric etodolac (32 mg/kg) did not modify basal gastric acid secretion. Our data suggest that etodolac, a selective COX-2 inhibitor, impairs gastric mucosal resistance and can exacerbate gastric mucosal injury caused by other mucosal barrier breaking agents. Cyclooxygenase type-2 thus contributes to the gastric mucosal defences. |
| Databáze: | OpenAIRE |
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