Antimicrobial activity of tigecycline and comparative agents against clinical isolates of staphylococci and enterococci from ICUs and general hospital wards at three Swedish university hospitals

Autor:	Goeran Kronvall, Mats Walder, Mikael Sörberg, Carina Claesson, Lennart E. Nilsson
Rok vydání:	2009
Předmět:	Microbiology (medical) Staphylococcus Minocycline Microbial Sensitivity Tests Tigecycline Polymerase Chain Reaction Tazobactam Statistics Nonparametric Microbiology Hospitals University chemistry.chemical_compound Bacterial Proteins Intensive care Patients' Rooms medicine Humans Carbon-Oxygen Ligases Antibacterial agent Sweden General Immunology and Microbiology biology business.industry Vancomycin Resistance General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Anti-Bacterial Agents Intensive Care Units Infectious Diseases Enterococcus chemistry Linezolid bacteria Vancomycin Methicillin Resistance business medicine.drug Piperacillin
Zdroj:	Scandinavian Journal of Infectious Diseases. 41:171-181
ISSN:	1651-1980 0036-5548
Popis:	The activities of tigecycline and comparative agents on staphylococci and enterococci isolated from patients at general hospital wards (GHWs) and intensive care units (ICUs) at 3 university hospitals in Sweden were investigated. Oxacillin disc diffusion and minimal inhibitory concentration with E-test were used. The presence of mecA, vanA or vanB genes was determined with PCR. Statistically significant higher incidence of clindamycin, fusidic acid, rifampicin and multidrug-resistant CoNS was found at ICUs compared to GHWs. Resistance rates were low among S. aureus. Tigecycline, linezolid and vancomycin were the only agents with high activity against methicillin-resistant S. aureus and multidrug-resistant CoNS. Resistance rates were low among E. faecalis, except for high-level gentamicin-resistant (HLGR) E. faecalis. E. faecium showed high resistance rates to ampicillin, piperacillin/tazobactam and imipenem. The HLGR rates among E. faecium were lower than the rates for E. faecalis. Tigecycline and linezolid were the only drugs with high activity against all enterococci including vancomycin-resistant enterococci. No statistically significant differences in susceptibility rates were found between the ward levels for S. aureus and enterococcal isolates and no statistically significant differences were found between the hospitals.
Databáze:	OpenAIRE
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