Evaluation of serum lipid concentrations among U.S. workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
| Autor: | G M, Calvert, K K, Willie, M H, Sweeney, M A, Fingerhut, W E, Halperin |
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| Rok vydání: | 1996 |
| Předmět: |
Gerontology
Adult Male medicine.medical_specialty Polychlorinated Dibenzodioxins Adolescent chemistry.chemical_compound Reference Values Internal medicine Occupational Exposure Environmental Chemistry Medicine Humans heterocyclic compounds Triglycerides General Environmental Science Triglyceride business.industry Public Health Environmental and Occupational Health Lipid metabolism Tetrachlorodibenzo-p-dioxin United States Endocrinology Cholesterol Cross-Sectional Studies chemistry Evaluation Studies as Topic Toxicity Linear Models Female Occupational exposure business |
| Zdroj: | Archives of environmental health. 51(2) |
| ISSN: | 0003-9896 |
| Popis: | 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism in animals; however, evidence for such an effect in humans is conflicting. This conflict was addressed using data from a cross-sectional medical study conducted between 1987 and 1988. The exposed participants had been employed at least 15 y earlier in the manufacture of 2,4,5-trichlorophenol or one of its derivatives at two chemical plants in the United States. A total of 281 workers and 260 unexposed referents participated. Workers had substantial exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, evidenced by a median serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration of 406.6 femtograms/gram of serum (fg/g serum), compared with 36.9 fg/g serum among the referents. A slight association between triglyceride concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration was found (p = .05). Over the range of observed 2,3,7,8-tetrachlorodibenzo-p-dioxin values (i.e., 37-19000 fg/g serum), triglyceride concentration increased only about 0.4 mmol/I. No association was found between an abnormally elevated triglyceride (i.e.,2.82 mmol/I) concentration and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration. An association was also found between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentration and an abnormal high-density lipoprotein concentration (p = .09). in summary, there was evidence of an effect on lipid metabolism in a group of workers with high serum 2,3,7,8-tetrachlorodibenzo-p-dioxin concentrations. The influence of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid concentrations, however, was small, compared with the influence of other factors. |
| Databáze: | OpenAIRE |
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