Vasculitis damage index in Behçet’s disease
| Autor: | Ibrahem Siam, Tamer A. Gheita, Ahmed M. Soliman, Sherif M. Gamal, Nesreen Sobhy, Fatema T. Elgengehy, Ghada Wahby El-Hady |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physical examination Behcet's disease Diseases of the musculoskeletal system Vasculitis damage index Gastroenterology 03 medical and health sciences Behçet’s disease 0302 clinical medicine Rheumatology Internal medicine medicine 030212 general & internal medicine Stroke 030203 arthritis & rheumatology medicine.diagnostic_test Vascular disease business.industry Egyptian Patients RC581-607 medicine.disease Comorbidity RC925-935 Immunologic diseases. Allergy business Vasculitis Systemic vasculitis |
| Zdroj: | Advances in Rheumatology, Vol 61, Iss 1, Pp 1-7 (2021) |
| ISSN: | 2523-3106 |
| Popis: | Background Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet’s disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet’s disease (BD) to determine if VDI could be used to assess damage in patients with BD. Methods A total of 109 patients with BD were recruited from the Rheumatology Department (outpatient and inpatient clinic), Cairo University Hospitals. All patients were subjected to full history taking, clinical examination, and routine laboratory investigations. Disease activity was assessed by the BD current activity form, and the VDI was calculated in all patients. The relationship of the VDI to the disease clinical manifestations was studied. Mann–Whitney and Kruskal Wallis tests were used to estimate differences in quantitative variables. Spearman correlation test was used to test for correlation between quantitative variables. Results In the current study, the VDI ranged from 1 to 10, with a mean of 3.5 ± 1.8. It was significantly associated with total thrombosis (P = 0.022); total neurological manifestations (P = 0.000), especially stroke and cranial nerve affection; uveitis (P = 0.005); avascular necrosis (AVN) (P = 0.015); osteoporosis (P = 0.01); impaired vision (P P P = 0.012). Generally, immunosuppressive treatment was significantly associated with VDI (P = 0.039), especially cyclophosphamide (P P = 0.008), chlorambucil (P = 0.003), and anticoagulant (P = 0.02). VDI was also significantly correlated with age (P = 0.033), disease duration (P = 0.029), and duration of eye involvement (P = 0.003). Conclusion VDI is significantly associated with most disease parameters of BD, except for parameters such as mucocutaneous manifestations and uncomplicated venous thrombosis; however, further studies may be needed to establish BD-specific damage index. |
| Databáze: | OpenAIRE |
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