Alcohol dependence severity determines the course of treatment‐seeking patients
| Autor: | Chie Iwahara, Yasunobu Komoto, Akira Yokoyama, Sachio Matsushita, Mitsuru Kimura, Susumu Higuchi, Atsushi Yoshimura, Tomomi Tohyama, Junichi Yoneda, Hitoshi Maesato, Hiroshi Sakuma, Tsuyoshi Takimura, Yosuke Yumoto, Takeshi Mizukami, Hideki Nakayama |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Temperance media_common.quotation_subject Psychological intervention Medicine (miscellaneous) Motivational Interviewing macromolecular substances Toxicology Severity of Illness Index Recurrence Internal medicine Adaptation Psychological Humans Medicine Prospective Studies Relapse risk Prospective cohort study media_common Treatment seeking business.industry Proportional hazards model Alcohol dependence Middle Aged Patient Acceptance of Health Care Abstinence Alcoholism Psychiatry and Mental health Treatment Outcome Controlled drinking Female business |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 45:2335-2346 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/acer.14707 |
| Popis: | BACKGROUND While accumulating evidence suggests a relation between the severity of alcohol dependence and the risk of its recurrence, the impact of dependence severity on the course of the disorder has not been carefully evaluated. The present study examined the impact of several severity indices of alcohol dependence on the drinking course after inpatient treatment. METHODS This prospective study was conducted over a 12-month period following alcohol treatment at a specialized hospital. A total of 712 consecutively admitted alcohol-dependent patients were targeted for enrollment at the time of their hospitalization, with 637 patients registered and followed. The characteristics and severity of the subjects were assessed using multiple methods at admission, with their course after discharge followed continuously using mailed questionnaires that queried them regarding their drinking behavior. RESULTS Greater severity of dependence, assessed using the number of ICD-10 diagnostic criteria met, was associated with a lower rate of abstinence during the study period (p = 0.035). The rate of abstinence also decreased significantly as the baseline blood gamma-glutamyl transferase value and Alcohol Dependence Scale (ADS) score increased (p = 0.031 and p = 0.0002, respectively). In multivariate Cox proportional hazards analyses, the group with the most severe ADS scores had a significantly greater risk of relapse to drinking than the group with the least severe scores (HR = 2.67, p = 0.001). Dependence severity also associated with the drinking pattern; participants in both the controlled drinking group and the abstinence group had lower ADS scores at admission and a later age at first drinking (p = 0.001 and p |
| Databáze: | OpenAIRE |
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