Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas
| Autor: | Zhang Lian-Qun, Song Xin, Zhao Xue-Ke, Huang Jia, Zhang Peng, Wang Lu-Wen, Meng Hui, Ku Jian-Wei, Kong Guo-Qiang, Jiang Tao, Li Xin-Min, Lv Xiao-Long, Ma Teng, Yuan Guo, Wu Min-Jie, Hu Shou-Jia, Lv Shuang, Zhang Tang-Juan, Ji Ling-Fen, Fan Zong-Min, Wang Neng-Chao, Zhang Yao-Wen, Zhou Fu-You, Wang Li-Dong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Multivariate statistics medicine.medical_specialty Gastric cardia adenocarcinoma Biology Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine immune system diseases Polymorphism (computer science) Internal medicine Genotype medicine cardiovascular diseases Allele skin and connective tissue diseases ALDH2 Traditional medicine Incidence (epidemiology) Odds ratio Gastric Cardia Adenocarcinoma lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens rs671 030104 developmental biology Oncology 030220 oncology & carcinogenesis cardiovascular system |
| Zdroj: | Cancer Biology & Medicine, Vol 14, Iss 1, Pp 60-65 (2017) |
| ISSN: | 2095-3941 |
| Popis: | Objective : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 (ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma (ESCC).Methods : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China. TaqMan allele discrimination assay was used to genotype the rs671 polymorphism. χ2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA, and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results : Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population (P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in high-incidence areas for both GCA and ESCC was lower than that in low-incidence areas (PConclusions : Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|