Anomalous transverse relaxation in 1H spectroscopy in human brain at 4 Tesla

Autor: Robert C. Risinger, Denis Le Bihan, S. Posse, Robert S. Balaban, Charles A. Cuenod
Přispěvatelé: Department of Health and Human Services, National Institutes of Health [Bethesda] (NIH), Méthodes d'imagerie des échanges transcapillaires (LRI), IFR94-Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Recherche en Imagerie LRI-EA4062, Université Paris Descartes - Paris 5 (UPD5), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Univ Fed Rio Grande do Norte, Dept Chem (LAPET), Univ Fed Rio Grande do Norte, Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), National Institutes of Health ( NIH ), Méthodes d'imagerie des échanges transcapillaires ( LRI ), IFR94-Université Paris Descartes - Paris 5 ( UPD5 ), Université Paris Descartes - Paris 5 ( UPD5 ), National Institutes of Health [Bethesda] ( NIH ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Univ Fed Rio Grande do Norte, Dept Chem ( LAPET ), Le Bihan, Denis
Jazyk: angličtina
Rok vydání: 1995
Předmět:
Intracellular Fluid
MESH : Motion
Magnetic Resonance Spectroscopy
Proton
Phosphocreatine
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Analytical chemistry
MESH : Aspartic Acid
MESH: Signal Processing
Computer-Assisted
MESH: Aspartic Acid
MESH : Artifacts
MESH : Choline
030218 nuclear medicine & medical imaging
Choline
Diffusion
Paramagnetism
chemistry.chemical_compound
0302 clinical medicine
Nuclear magnetic resonance
[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Fourier Analysis
MESH: Creatine
MESH: Intracellular Fluid
MESH : Hydrogen
Relaxation (NMR)
MESH: Hydrogen
MESH: Choline
Brain
Pulse sequence
Signal Processing
Computer-Assisted
MESH: Diffusion
Nuclear magnetic resonance spectroscopy
Human brain
MESH : Creatine
medicine.anatomical_structure
MESH: Artifacts
MESH : Electron Spin Resonance Spectroscopy
Occipital Lobe
MESH: Image Enhancement
Artifacts
MESH: Occipital Lobe
MESH: Motion
MESH: Phosphocreatine
03 medical and health sciences
Motion
MESH: Brain
MESH: Body Water
Body Water
medicine
Humans
Radiology
Nuclear Medicine and imaging
MESH : Phosphocreatine
Spectroscopy
MESH : Diffusion
Aspartic Acid
MESH : Signal Processing
Computer-Assisted
MESH : Body Water
MESH : Occipital Lobe
MESH: Humans
MESH: Magnetic Resonance Spectroscopy
MESH : Humans
Electron Spin Resonance Spectroscopy
Creatine
Image Enhancement
nervous system diseases
MESH : Fourier Analysis
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging
chemistry
MESH : Brain
nervous system
MESH : Image Enhancement
MESH : Magnetic Resonance Spectroscopy
MESH: Electron Spin Resonance Spectroscopy
030217 neurology & neurosurgery
MESH: Fourier Analysis
Hydrogen
MESH : Intracellular Fluid
Zdroj: Magnetic Resonance in Medicine
Magnetic Resonance in Medicine, Wiley, 1995, 33 (2), pp.246-52
Magnetic Resonance in Medicine, 1995, 33 (2), pp.246-52
ISSN: 0740-3194
1522-2594
Popis: International audience; Longitudinal (T1) and apparent transverse relaxation times (T2) of choline-containing compounds (Cho), creatine/phosphocreatine (Cr/PCr), and N-acetyl aspartate (NAA) were measured in vivo in human brain at 4 Tesla. Measurements were performed using a water suppressed stimulated echo pulse sequence with complete outside volume presaturation to improve volume localization at short echo times. T1-values of Cho (1.2 +/- 0.1 s), Cr (1.6 +/- 0.3 s), and NAA (1.6 +/- 0.2 s) at 4 Tesla in occipital brain were only slightly larger than those reported in the literature at 1.5 Tesla. Thus, TR will not adversely affect the expected enhancement of signal-to-noise at 4 Tesla. Surprisingly, apparent T2-values of Cho (142 +/- 34 ms), Cr (140 +/- 13 ms), and NAA (185 +/- 24 ms) at 4 Tesla were significantly smaller than those at 1.5 Tesla and further decreased when increasing the mixing interval TM. Potential contributing factors, such as diffusion in local susceptibility related gradients, dipolar relaxation due to intracellular paramagnetic substances and motion effects are discussed. The results suggest that short echo time spectroscopy is advantageous to maintain signal to noise at 4 Tesla.
Databáze: OpenAIRE
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