Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR’s toxicological profile database
| Autor: | Melanie C. Buser, Hana R. Pohl, Henry G. Abadin |
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| Rok vydání: | 2020 |
| Předmět: |
Databases
Factual Database business.industry Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Endocrine System General Medicine Environmental exposure 010501 environmental sciences computer.software_genre 01 natural sciences Pollution Article Rats 03 medical and health sciences 0302 clinical medicine Disease registry Animals Medicine 030212 general & internal medicine Sensitivity (control systems) business computer 0105 earth and related environmental sciences |
| Zdroj: | Int J Environ Health Res |
| ISSN: | 1369-1619 0960-3123 |
| DOI: | 10.1080/09603123.2020.1772204 |
| Popis: | This review utilizes the robust database of literature contained in toxicological profiles developed by the Agency for Toxic Substances and Disease Registry. The aim was to use this database to identify developmental toxicity studies reporting alterations in hormone levels in the developing fetus and offspring and identify windows of sensitivity. We identified 74 oral exposure studies in rats that provided relevant information on 30 chemicals from 21 profiles. Most studies located provided information on thyroid hormones, with fewer studies on anterior pituitary, adrenal medulla, ovaries, and testes. No studies pertaining to hormones of the posterior pituitary, pancreas, or adrenal cortex were located. The results demonstrate that development of the endocrine system may be affected by exposure to environmental contaminants at many different points, including gestational and/or lactational exposure. Moreover, this review demonstrates the need for more developmental toxicity studies focused on the endocrine system and specifically alterations in hormone levels. |
| Databáze: | OpenAIRE |
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