Effect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats
| Autor: | Ezel Taşdemir, Cemil Tümer, Abdurrahman Şermet, Hüda Diken, Hakkı Murat Bilgin, Basra Deniz Obay |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty Physiology Peptide Hormones Clinical Biochemistry Growth hormone secretagogue receptor Biochemistry Nitric oxide Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Immune system Phagocytosis Enos Internal medicine medicine Animals Macrophage Rats Wistar Receptor Nitrites biology digestive oral and skin physiology biology.organism_classification Ghrelin Rats Cold Temperature Nitric oxide synthase chemistry Macrophages Peritoneal biology.protein Injections Intraperitoneal hormones hormone substitutes and hormone antagonists |
| Zdroj: | Regulatory Peptides. 138:113-117 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2006.08.010 |
| Popis: | Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, was identified in the rat stomach. This peptide acts through nitric oxide (NO) by expressing endothelial nitric oxide synthase (eNOS) and down regulating inducible nitric oxide synthase (iNOS) at its gastroproprotective effect against restraint stress induced damage. Recently the ghrelin receptor has also been detected in peripheral systems including immune tissue. We have investigated the possible effect of ghrelin on phagocytic activity of peritoneal macrophages in acute cold-restraint stress (ACRS) exposed rats. The rats were divided into control, stress and ghrelin groups. In ghrelin groups, single dose and three days consecutive dose of ghrelin (20 μg/kg. i.p.) were applied to rats that were exposed to ACRS for 4 h. 1 ml of saline was injected i.p. after ACRS for 3 consecutive days to the rats of the stress groups. Ghrelin administration reduced the increased phagocytic activity induced by ACRS. We conclude that ghrelin exerts an important role at macrophage phagocytic activity in ACRS exposed rats. |
| Databáze: | OpenAIRE |
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