Tutankhamun’s Antimalarial Drug for Covid-19
| Autor: | Horst-Dieter Försterling, Andrei P. Sommer, Katlin E. Sommer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Coronavirus disease 2019 (COVID-19) Famous Persons anti-inflammatory drugs Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) media_common.quotation_subject Nigella sativa coronavirus thymoquinone Predictive capability Antiviral Agents Antimalarials antiviral drugs 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery Benzoquinones Humans Medicine antibacterial drugs History Ancient Thymoquinone 030304 developmental biology media_common 0303 health sciences Traditional medicine SARS-CoV-2 business.industry Drug Repositioning biopharmaceuticals General Medicine medicine.disease COVID-19 Drug Treatment antiparasitic drugs Drug repositioning chemistry 030220 oncology & carcinogenesis Egypt Original Article business Malaria |
| Zdroj: | Drug Research |
| ISSN: | 2194-9387 2194-9379 |
| Popis: | Drug repositioning is a strategy that identifies new uses of approved drugs to treat conditions different from their original purpose. Current efforts to treat Covid-19 are based on this strategy. The first drugs used in patients infected with SARS-CoV-2 were antimalarial drugs. It is their mechanism of action, i. e., rise in endosomal pH, which recommends them against the new coronavirus. Disregarding their side effects, the study of their antiviral activity provides valuable hints for the choice and design of drugs against SARS-CoV-2. One prominent drug candidate is thymoquinone, an antimalarial substance contained in Nigella sativa – most likely one of the first antimalarial drugs in human history. Since the outbreak of the pandemic, the number of articles relating thymoquinone to Covid-19 continuously increases. Here, we use it as an exemplary model drug, compare its antiviral mechanism with that of conventional antimalarial drugs and establish an irreducible parametric scheme for the identification of drugs with a potential in Covid-19.Translation into the laboratory is simple. Starting with the discovery of Nigella sativa seeds in the tomb of Pharaoh Tutankhamun, we establish a physicochemical model for the interaction of thymoquinone with both coronavirus and cells. Exploiting the predictive capability of the model, we provide a generalizable scheme for the systematic choice and design of drugs for Covid-19. An unexpected offshoot of our research is that Tutankhamun could not have died of malaria, a finding contrary to the mainstream theory. |
| Databáze: | OpenAIRE |
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