Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response
| Autor: | Jacques Micheau, Robert Jaffard, Aline Desmedt, Ludovic Calandreau, Pierre Trifilieff, Marc Marien, Nicole Mons, Aline Marighetto, Laurence Costes |
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| Přispěvatelé: | Centre National de la Recherche Scientifique (CNRS), Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), Centre de Recherche Pierre Fabre (Centre de R&D Pierre Fabre), PIERRE FABRE |
| Rok vydání: | 2006 |
| Předmět: |
Male
Conditioned emotional response [SDV]Life Sciences [q-bio] Emotions Stimulus (physiology) Hippocampal formation Hippocampus Amygdala Mice 03 medical and health sciences 0302 clinical medicine Adaptation Psychological Conditioning Psychological medicine Animals Fear conditioning ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences General Neuroscience Classical conditioning Extracellular Fluid Fear Articles Acetylcholine Mice Inbred C57BL medicine.anatomical_structure COMPOSE DE L'AMMONIUM NEUROPHYSIOLOGIE Cholinergic Psychology Neuroscience HYPPOCAMPUS 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2006, 26 (52), pp.13556-13566. ⟨10.1523/JNEUROSCI.3713-06.2006⟩ |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | Ample data indicate that tone and contextual fear conditioning differentially require the amygdala and the hippocampus. However, mechanisms subserving the adaptive selection among environmental stimuli (discrete tone vs context) of those that best predict an aversive event are still elusive. Because the hippocampal cholinergic neurotransmission is thought to play a critical role in the coordination between different memory systems leading to the selection of appropriate behavioral strategies, we hypothesized that this cholinergic signal may control the competing acquisition of amygdala-mediated tone and contextual conditioning. Using pavlovian fear conditioning in mice, we first show a higher level of hippocampal acetylcholine release and a specific pattern of extracellular signal-regulated kinase 1/2 (ERK1/2) activation within the lateral (LA) and basolateral (BLA) amygdala under conditions in which the context is a better predictor than a discrete tone stimulus. Second, we demonstrate that levels of hippocampal cholinergic neurotransmission are causally related to the patterns of ERK1/2 activation in amygdala nuclei and actually determine the selection among the context or the simple tone the stimulus that best predicts the aversive event. Specifically, decreasing the hippocampal cholinergic signal not only impaired contextual conditioning but also mimicked conditioning to the discrete tone, both in terms of the behavioral outcome and the LA/BLA ERK1/2 activation pattern. Conversely, increasing this cholinergic signal not only disrupted tone conditioning but also promoted contextual fear conditioning. Hence, these findings highlight that hippocampal cholinergic neurotransmission controls amygdala function, thereby leading to the selection of relevant emotional information. |
| Databáze: | OpenAIRE |
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