Bats Worldwide Carry Hepatitis E Virus-Related Viruses That Form a Putative Novel Genus within the Family Hepeviridae
| Autor: | Annika Seelen, Alexander C. Adam, Florian Gloza-Rausch, Samuel K. Oppong, Eric M. Leroy, Marcel A. Müller, Jan Felix Drexler, Rainer G. Ulrich, Christian Drosten, Stefan M. Klose, Andreas Osterman, Yaw Adu-Sarkodie, Adriana Fumie Tateno, Veronika M. Cottontail, Victor M. Corman, Rodrigo Melim Zerbinati, Andrea Rasche, Alexander N. Lukashev, Elisabeth K. V. Kalko |
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| Rok vydání: | 2012 |
| Předmět: |
Asia
Genotype viruses Molecular Sequence Data Immunology Zoology Orthohepevirus Biology medicine.disease_cause Microbiology Virus Hepevirus Feces Open Reading Frames Viral Proteins 03 medical and health sciences Hepatitis E virus Phylogenetics Chiroptera Zoonoses Virology medicine Animals Humans Clade Phylogeny 030304 developmental biology 0303 health sciences Phylogenetic tree 030306 microbiology Australia Genetic Variation Hepatitis E medicine.disease biology.organism_classification 3. Good health Hepeviridae Europe Genetic Diversity and Evolution Insect Science Africa Americas |
| Zdroj: | Journal of Virology Journal of Virology; Vol 86 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis in tropical and temperate climates. Tropical genotypes 1 and 2 are associated with food-borne and waterborne transmission. Zoonotic reservoirs (mainly pigs, wild boar, and deer) are considered for genotypes 3 and 4, which exist in temperate climates. In view of the association of several zoonotic viruses with bats, we analyzed 3,869 bat specimens from 85 different species and from five continents for hepevirus RNA. HEVs were detected in African, Central American, and European bats, forming a novel phylogenetic clade in the family Hepeviridae . Bat hepeviruses were highly diversified and comparable to human HEV in sequence variation. No evidence for the transmission of bat hepeviruses to humans was found in over 90,000 human blood donations and individual patient sera. Full-genome analysis of one representative virus confirmed formal classification within the family Hepeviridae . Sequence- and distance-based taxonomic evaluations suggested that bat hepeviruses constitute a distinct genus within the family Hepeviridae and that at least three other genera comprising human, rodent, and avian hepeviruses can be designated. This may imply that hepeviruses invaded mammalian hosts nonrecently and underwent speciation according to their host restrictions. Human HEV-related viruses in farmed and peridomestic animals might represent secondary acquisitions of human viruses, rather than animal precursors causally involved in the evolution of human HEV. |
| Databáze: | OpenAIRE |
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