Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
| Autor: | Patrice Fort, Zachary B. Sluzala, Ashutosh Phadte |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death Physiology Clinical Biochemistry Disease Review RM1-950 medicine.disease_cause Biochemistry recombinant proteins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation medicine oxidative stress alpha-crystallin Molecular Biology Loss function biology business.industry Neurodegeneration neurodegeneration Retinal Cell Biology medicine.disease 030104 developmental biology chemistry Chaperone (protein) 030221 ophthalmology & optometry biology.protein Therapeutics. Pharmacology business Neuroscience Oxidative stress |
| Zdroj: | Antioxidants, Vol 10, Iss 1001, p 1001 (2021) Antioxidants |
| ISSN: | 2076-3921 |
| Popis: | The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death. While originally known and described for their role in the lens, the upregulation of these proteins in cells and animal models of neurodegenerative diseases highlighted their involvement in adaptive protective responses to neurodegeneration associated stress. However, several studies also suggest that chronic neurodegenerative conditions are associated with progressive loss of function of these proteins. Thus, while external supplementation of α-crystallin shows promise, their potential as a protein-based therapeutic for the treatment of chronic neurodegenerative diseases remains ambiguous. The current review aims at assessing the current literature supporting the anti-apoptotic potential of αA- and αB-crystallins and its potential involvement in retinal neurodegenerative diseases. The review further extends into potentially modulating the chaperone and the anti-apoptotic function of α-crystallins and the use of such functionally enhanced proteins for promoting neuronal viability in retinal neurodegenerative disease. |
| Databáze: | OpenAIRE |
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