The Flavonoid Luteolin Increases the Resistance of Normal, but Not Malignant Keratinocytes, Against UVB-Induced Apoptosis
| Autor: | Katrien Smaers, Charlotte M. Proby, Daniel H. Maes, Sofie Van Kelst, Lien Verschooten, Marjan Garmyn, Patrizia Agostinis, Lieve Declercq |
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| Rok vydání: | 2010 |
| Předmět: |
Keratinocytes
Programmed cell death Skin Neoplasms Cell Survival Ultraviolet Rays Cell Sunburn Apoptosis Inflammation Dermatology Biology Biochemistry Antioxidants chemistry.chemical_compound INFLAMMATION Cell Line Tumor medicine Humans Luteolin skin and connective tissue diseases DIETARY FLAVONOIDS Molecular Biology Carcinogen Science & Technology integumentary system DEATH TOPICAL APPLICATION EXTRACT PHOTOPROTECTION Cell Biology CANCER SUNBURN CELL medicine.anatomical_structure chemistry UVB-induced apoptosis PHOTOCARCINOGENESIS Cytoprotection Immunology Carcinoma Squamous Cell Cancer research medicine.symptom Keratinocyte Life Sciences & Biomedicine SKIN |
| Zdroj: | Journal of Investigative Dermatology. 130:2277-2285 |
| ISSN: | 0022-202X |
| DOI: | 10.1038/jid.2010.124 |
| Popis: | Adequate protection of skin against the carcinogenic effects of UVB irradiation is essential. Flavonoids may have a conspicuous role in cancer prevention because of their antioxidant, anti-inflammatory, and growth-inhibitory effects. Therefore, we tested the effects of the flavone luteolin (LUT) on selected parameters of the sunburn response in normal human keratinocytes, exposed to physiological doses of UVB. LUT attenuated UVB-induced cell death through delay and inhibition of intrinsic apoptotic signaling. Moreover, LUT not only predominantly affected the mitochondrial apoptosis pathway through its antioxidant capacity, but also changed the balance of Bcl2 (B-cell leukemia/lymphoma 2)-family members. Furthermore, LUT had inhibitory effects on the UVB-induced release of the inflammatory mediators, IL-1alpha and prostaglandin-E(2). Using different cell lines derived from squamous cell carcinomas, we showed that LUT did not increase the resistance of malignant keratinocytes to UVB. Our data suggest that LUT inhibits different aspects of the sunburn response, which results ultimately in an increased survival of normal keratinocytes, whereas the sensitivity of malignant cells to UVB remain unchanged. Hence, LUT might have value in new photoprotective applications or improve existing ones.Journal of Investigative Dermatology advance online publication, 13 May 2010; doi:10.1038/jid.2010.124. ispartof: Journal of Investigative Dermatology vol:130 issue:9 pages:2277-2285 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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