Molecular basis of discrepancies in neurotoxic properties among 1-methyl-4-aryl-1,2,3,6-tetrahydropyridines
| Autor: | Ludmila G. Dubova, Nadegda N. Lermontova, Sergey O. Bachurin, Sergey E. Tkachenko, L. S. Solyakov, Sergey O. Sablin |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Stereochemistry
Monoamine oxidase Dopamine Metabolite Dopamine Agents Guinea Pigs Mitochondria Liver In Vitro Techniques Mice Norepinephrine Structure-Activity Relationship chemistry.chemical_compound medicine Animals Structure–activity relationship Parkinson Disease Secondary Monoamine Oxidase Molecular Biology Brain Chemistry Neurons General Neuroscience MPTP Dopaminergic MPTP Poisoning Substrate (chemistry) Mice Inbred C57BL Kinetics chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Nerve Degeneration Neurology (clinical) Synaptosomes medicine.drug |
| Zdroj: | Molecular and Chemical Neuropathology. 17:189-200 |
| ISSN: | 1044-7393 |
| DOI: | 10.1007/bf03160009 |
| Popis: | The relationship between structural specificity of the main stages of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) action and the display of parkinsonogenic properties among homologous structures in a number of 4-tolyl derivatives of MPTP has been studied. All the compounds are better substrates for monoamine oxidase (MAO) than MPTP. MAO is inactivated during the reaction according to a mechanism of irreversible inhibition by 2,3-dihydropyridinium metabolite. All the tolyl derivatives are stronger inhibitors of MAO than 1-methyl-2,3-dihydropyridinium (MPDP). A significant contribution of enzyme inhibition to the catalytic conversion of the substrate leads to the fact that substrates having equal (para isomer) or even higher (meta isomer) values of catalytic parameters are oxidized by MAO to a lesser extent than MPTP. It has been found that all 4-arylpyridiniums (final products of MATP bioconversion) competitively and reversibly inhibit [14C]dopamine (DA) uptake in mouse brain synaptosomes. Affinity toward DA transporter characterized by KI (microM) is 0.37 +/- 0.04, 0.7 +/- 0.1, 2.0 +/- 0.15, 2.0 +/- 0.35 for MPP, and its o-, m-, and p-tolyl derivatives, respectively. Joint calculation of specificity factors for the processes discussed define the following rank order for the bio-delivery of MATP's metabolic produces into DA nerve terminals: o-tolylMPTPm-tolylp-tolyl. The regularity revealed is in good agreement with the observed relative potency of these compounds to cause dopaminergic neurodegeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink