Fever of unknown origin in a patient with common variable immunodeficiency associated with multisystemic granulomatous disease
| Autor: | Juan-Manuel Guerra-Vales, Martánez-GonzÁlez Miguel-íngel, Ruiz-Contreras Jesús, Castelbón-Fernández Francisco-Javier, Garfia-Castillo Cristina, Rodriguez-Gil Yolanda, Mario Fernández-Ruiz |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Anti-Inflammatory Agents Malignancy Granulomatous Disease Chronic Fever of Unknown Origin Diagnosis Differential Prednisone Internal Medicine medicine Humans Fever of unknown origin Granuloma business.industry Common variable immunodeficiency Liver Diseases General Medicine medicine.disease Occult medicine.anatomical_structure Common Variable Immunodeficiency Female Sarcoidosis Bone marrow Differential diagnosis business Tomography X-Ray Computed medicine.drug |
| Zdroj: | Internal medicine (Tokyo, Japan). 46(15) |
| ISSN: | 1349-7235 |
| Popis: | Non-caseating epithelioid granulomas have been described in a small number of patients with common variable immunodeficiency (CVID). We report a 26-year-old woman diagnosed with CVID nine years earlier, who developed non-caseating granulomas in the liver, bone marrow and skin. She was referred to our department for a fever of more than one year duration without apparent focus. Extensive search for underlying malignancy or occult infection was unremarkable. Empirical treatment with prednisone was begun and the patient showed a marked improvement. The literature on the association between CVID and non-caseating granulomatous disease, and the differential diagnosis of hepatic granulomas as a cause of fever of unknown origin, is also reviewed. |
| Databáze: | OpenAIRE |
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