Author Correction:GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
| Autor: | Peter K. Joshi, Peter Kraft, Tõnu Esko, Nora Franceschini, James F. Wilson, Paul M. McKeigue, Lude Franke, Kari E. North, Marco Colombo, Marilyn C. Cornelis, Athina Spiliopoulou, NaNa Keum, Paul S. de Vries, Alanna C. Morrison, Edward Giovannucci, Nicola Pirastu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Risk Published Erratum Science General Physics and Astronomy Genome-wide association study Biology Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Surveys and Questionnaires medicine Humans Genetic Predisposition to Disease Prospective Studies Author Correction Multidisciplinary Alopecia General Chemistry Heritability medicine.disease 030104 developmental biology Evolutionary biology Susceptibility locus Male-pattern baldness Genome-Wide Association Study |
| Zdroj: | Pirastu, N, Joshi, P K, de Vries, P S, Cornelis, M C, McKeigue, P M, Keum, N, Franceschini, N, Colombo, M, Giovannucci, E L, Spiliopoulou, A, Franke, L, North, K E, Kraft, P, Morrison, A C, Esko, T & Wilson, J F 2018, ' Author Correction : GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk ', Nature Communications, vol. 9, no. 1, pp. 2536 . https://doi.org/10.1038/s41467-018-04857-7 Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018) Nature Communications |
| Popis: | Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan and cancer. Our study not only greatly increases the number of MPB loci, illuminating the genetic architecture, but also provides a new approach to disentangling the shared biological pathways underlying complex diseases. |
| Databáze: | OpenAIRE |
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