Atrial fibrillation after resection: a PROGRESS III study
| Autor: | Matthew Wilson, Mike Bradburn, Matthew Lee, J. Lee, S. R. Brown, D. J. Hawkins |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Colorectal cancer medicine.drug_class Resection 03 medical and health sciences 0302 clinical medicine Internal medicine Atrial Fibrillation medicine Natriuretic peptide Humans Blood test Statistical analysis cardiovascular diseases medicine.diagnostic_test business.industry Incidence Gastroenterology Cardiac arrhythmia Atrial fibrillation Exploratory analysis medicine.disease 030220 oncology & carcinogenesis Quality of Life Cardiology 030211 gastroenterology & hepatology business Biomarkers |
| Zdroj: | Colorectal Disease. 23:307-315 |
| ISSN: | 1463-1318 1462-8910 |
| Popis: | Aim Atrial fibrillation (AF) is a common cardiac arrhythmia, and is associated with worsening quality of life and complications such as stroke. Previous work showed that 8% of patients develop new‐onset AF following colonic resection and highlighted factors that might predict the development of postoperative AF. The development of a new arrhythmia may have a negative effect on longer‐term quality of life as well as cancer survivorship. The aim of this study is to accurately quantify the incidence of AF following colorectal cancer surgery and to validate a model to predict its development. Method The Atrial Fibrillation After Resection (AFAR) study will recruit 720 patients aged 65 or over undergoing resection of colorectal cancer with curative intent. The primary outcome is development of AF within 90 days of surgery. Assessment of cardiac rhythm will be performed using 24‐h Holter monitors at baseline, 30 and 90 days after surgery. An electrocardiogram (ECG) will be performed on the day of discharge. Baseline descriptors including model variables and quality of life will be recorded using EQ‐5D‐5L. The occurrence of complications and other key surgical outcomes will be recorded. An additional blood test for N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) will be performed prior to surgery. Statistical analysis will validate a previously derived model and will test the incremental value of added variables such as NT‐proBNP. Finally, an exploratory analysis will assess whether changes in ECG measures between baseline and postoperative ECG can predict subsequent new‐onset AF. Conclusion This study will provide data that may allow us to stratify the risk of developing AF following colorectal cancer surgery. This may inform screening or prophylactic approaches. |
| Databáze: | OpenAIRE |
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