Risk factors for invasive disease among children in Spain
| Autor: | Amparo Albert, Inmaculada Pereiró, Leopoldo Segarra, Alfredo Ballester, Amparo Morant, Javier Díez-Domingo |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
Male Pediatrics medicine.medical_specialty Haemophilus Infections Adolescent Population Meningitis Meningococcal Neisseria meningitidis medicine.disease_cause Tobacco smoke Pneumococcal Infections Risk Factors medicine Humans risk factors Risk factor education Child pneumoniae education.field_of_study business.industry Case-control study Haemophilus influenzae type b Infant Streptococcus Haemophilus influenzae Confidence interval Infectious Diseases Breast Feeding Logistic Models Streptococcus pneumoniae El Niño Social Class Spain Case-Control Studies Child Preschool invasive disease Female Tobacco Smoke Pollution business Breast feeding Day Care Medical |
| Zdroj: | JOURNAL OF INFECTION r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname |
| ISSN: | 0163-4453 |
| Popis: | Objective. To identify the risk factors related to invasive disease caused by Haemophilus influenzae type b (Hib), Neisseria meningitidis, and Streptococcus pneumoniae. Methods. Case-control. study. All hospitals of the region of Valencia in Spain (covering 95% of the population of Valencia). The patients are children aged less than 15 years in whom Hib, N. meningitidis or S. pneumoniae are isolated from normally sterile sites. Results. From 1995 to 1998, 275 cases of invasive disease were analysed, and 243 hospital controls were selected in the month after the onset of the case. The paediatrician completed a survey administered to the relatives at the time of admission. The risk factors related to invasive disease by Hib were exposure to tobacco smoke (number of smokers, adjusted OR (aOR) 1.74, 95% confidence interval (Cl) 1.02-2.96) and living with more than four people (aOR 3.72, 95% CI 1.3-3.7). For N. meningitidis, there is a dose-response retationship; if more than 60 cigarettes are smoked daily at home, the aOR is 3.61 (95% CI 1.04-12.57). If there are more than four people living in the household, aOR 1.69 (95% CI 1.01-2.85). In children under two years, of age, having siblings less than 15 years of age (OR 1.76, 95% CI 0.75-4.17) and attending a day nursery represents a risk for suffering invasive pneumococcal. disease (aOR 4.21, 95% CI 1.28-13.83). Conclusions. Among the variables tested, the modifiable risk factor is smoking; if smoking was reduced at home, the number of cases of invasive disease could be reduced in children, mainly in those under 5 years of age. Identification and vaccination of these risk groups would significantly reduce these diseases. (C) 2003 The British Infection Society. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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