Engineered fatty acid catabolism for fuel and chemical production
| Autor: | Ramon Gonzalez, Seohyoung Kim, Alexander Chou, Seokjung Cheong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Bioelectric Energy Sources Chemistry Pharmaceutical 030106 microbiology Biomedical Engineering chemistry.chemical_element Bioengineering Chemical production Metabolic engineering 03 medical and health sciences Animals Humans Organic chemistry Fatty acid catabolism Beta oxidation Alkyl Carbon chain chemistry.chemical_classification Fatty Acids Lipid Metabolism Metabolic Engineering chemistry Alcohols Surface modification Oxidation-Reduction Carbon Biotechnology |
| Zdroj: | Current Opinion in Biotechnology. 42:206-215 |
| ISSN: | 0958-1669 |
| Popis: | Fatty acid oxidation pathways are attractive for metabolic engineering purposes due to their cyclic nature as well as their reactions that allow for the selective functionalization of alkyl chains. These characteristics allow for the production of various chemicals, such as alcohols, alkanes, ketones and hydroxyacids, in a wide range of carbon numbers. To this end, the α-, β-, and ω-oxidation pathways have been engineered for use in various hosts. Furthermore, the β-oxidation pathway has been engineered to operate in reverse, resulting in a promising carbon chain elongation platform. This review will describe the recent progress in metabolic engineering strategies for the production of chemicals through these fatty acid oxidation pathways. |
| Databáze: | OpenAIRE |
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