Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis

Autor: Shih Chun Hua, Shih Ming Chen, Po Yeh Lin, Tzong-Huei Lee, Chia Yu Lin, Bi Li Chen, Pei Yun Tsai, Jen Ai Lee, Chia En Lin
Rok vydání: 2020
Předmět:
0301 basic medicine
Physiology
Urine
Biochemistry
White Blood Cells
Mice
chemistry.chemical_compound
Glomerulonephritis
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Medicine
Blood urea nitrogen
Nephritis
Multidisciplinary
Proteinuria
Glomerular basement membrane
Pyruvaldehyde
Body Fluids
medicine.anatomical_structure
Nephrology
Creatinine
030220 oncology & carcinogenesis
Anatomy
Cellular Types
medicine.symptom
Glomeruli
Research Article
medicine.medical_specialty
Histology
Science
Immune Cells
Urinary system
Immunology
Nephrotoxicity
03 medical and health sciences
Signs and Symptoms
Internal medicine
Animals
Lactic Acid
Oleanolic Acid
Blood Cells
business.industry
Macrophages
Biology and Life Sciences
Kidneys
Cell Biology
Renal System
Saponins
medicine.disease
Fibrosis
Mice
Inbred C57BL
030104 developmental biology
Endocrinology
chemistry
Clinical Medicine
business
Biomarkers
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0241053 (2020)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0241053
Popis: The relationship between methylglyoxal (MGO) and D-lactate during saikosaponin C (SSC) treatment of mice with accelerated nephrotoxic serum (NTS) nephritis was investigated. NTS nephritis was induced by administration of anti-basement membrane antibodies to C57BL/6 mice and three dosages of SSC were administered for 14 days. Proteinuria, blood urea nitrogen, serum creatinine, renal histology, urinary MGO and d-lactate changes were examined. Compared to the NTS control group, the middle dosage (10 mg/kg/day) of SSC significantly alleviated the development of nephritis based on urine protein measurements (34.40 ± 6.85 vs. 17.33 ± 4.79 mg/day, p
Databáze: OpenAIRE
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