Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome
Autor: | R. Ferreira, Francisco Sales Ávila Cavalcante, Fladimir de Lima Gondim, Maria Alexandra de Sousa Rios, Tiago Rocha Nogueira, Antônia Torres Ávila Pimenta, Daniel Silveira Serra |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Acute respiratory distress
Pharmacology 01 natural sciences chemistry.chemical_compound Airway resistance Smooth muscle Acute lung injury Medicine General Pharmacology Toxicology and Pharmaceutics Respiratory system Inflammatory cell infiltrate Lung function 010405 organic chemistry business.industry SARS-CoV-2 Pulmonary mechanics COVID-19 0104 chemical sciences Anacardic acids 010404 medicinal & biomolecular chemistry Antioxidant capacity chemistry Original Article business Infection |
Zdroj: | Revista Brasileira De Farmacognosia |
ISSN: | 1981-528X 0102-695X |
Popis: | Graphical abstract The acute respiratory distress syndrome caused by viral pathogens is a worldwide public health emergency. It is suggested that patients with this condition should be screened using therapies that address the need to prevent mortality. Anacardic acids found in Anacardium species have biological activities related to the antioxidant capacity of their double bonds in the lateral alkyl chain. The present study seeks to investigate the effects of anacardic acid monoene on acute respiratory distress syndrome caused by lipopolysaccharides. Experiments were carried out on mice divided into three groups: control group, acute respiratory distress-induced group, and anacardic acid monoene pretreated group, subsequently, induced to acute respiratory distress by lipopolysaccharides. Results showed that anacardic acid moeno was able to prevent changes in lung function and preserve its mechanical properties from containing inflammatory cell infiltrate, collapse of alveoli, and decreased airway resistance, suggesting that this compound may be effective in preventing the acute respiratory distress syndrome caused by viral pathogens. Supplementary Information The online version contains supplementary material available at 10.1007/s43450-021-00151-8. |
Databáze: | OpenAIRE |
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