Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus
| Autor: | Xianzhi Jiang, Nelson Osorio, Lbachir BenMohamed, Guey Chuen Perng, Roger Geertsema, Chinhui Hsiang, Donald J. Brown, Steven L. Wechsler |
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| Rok vydání: | 2015 |
| Předmět: |
reactivation
Stromal keratitis viruses Herpesvirus 1 Human Herpes simplex virus medicine.disease_cause Ophthalmology & Optometry Corneal blindness Recurrence 2.2 Factors relating to the physical environment Viral Aetiology stressed Sensory Systems Virus Latency Virus Shedding Infectious Diseases Female Rabbits Infection Human Corneal Stroma rabbit Biology Virus Article Herpetic Cellular and Molecular Neuroscience Animal model Immune system recurrent herpes stromal keratitis medicine Animals Eye Disease and Disorders of Vision Keratitis Herpesvirus 1 Animal DNA Virology Ophthalmology Disease Models Animal Tears Immunology Disease Models DNA Viral Rabbit model Keratitis Herpetic Sexually Transmitted Infections Virus Activation Heat-Shock Response |
| Zdroj: | Current eye research, vol 41, iss 3 |
| ISSN: | 1460-2202 |
| Popis: | AimRecurrent herpetic stromal keratitis (rHSK), due to an immune response to reactivation of herpes simplex virus (HSV-1), can cause corneal blindness. The development of therapeutic interventions such as drugs and vaccines to decrease rHSK have been hampered by the lack of a small and reliable animal model in which rHSK occurs at a high frequency during HSV-1 latency. The aim of this study is to develop a rabbit model of rHSK in which stress from elevated temperatures increases the frequency of HSV-1 reactivations and rHSK.Materials and methodsRabbits latently infected with HSV-1 were subjected to elevated temperatures and the frequency of viral reactivations and rHSK were determined.ResultsIn an experiment in which rabbits latently infected with HSV-1 were subjected to ill-defined stress as a result of failure of the vivarium air conditioning system, reactivation of HSV-1 occurred at over twice the normal frequency. In addition, 60% of eyes developed severe rHSK compared to |
| Databáze: | OpenAIRE |
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