High incidence of acquiring methicillin-resistant Staphylococcus aureus in Brazilian children with Atopic Dermatitis and associated risk factors
| Autor: | Kátia Regina Netto dos Santos, Fernanda Sampaio Cavalcante, Ekaterini Goudouris, Eliane de Dios Abad, Alexandre S. Rosado, Jan Dirk van Elsas, Alexandre Marques Paes da Silva, Cristina Barroso Hofer, Simone Saintive, Evandro Prado, Márcia Gonçalves Ribeiro, Dennis de Carvalho Ferreira |
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| Přispěvatelé: | Van Elsas lab |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male lcsh:QR1-502 MRSA medicine.disease_cause lcsh:Microbiology Cohort Studies 0302 clinical medicine Risk Factors Immunology and Allergy 030212 general & internal medicine SCORAD Prospective Studies Child medicine.diagnostic_test Incidence (epidemiology) Incidence General Medicine Atopic dermatitis Staphylococcal Infections Anti-Bacterial Agents Infectious Diseases Staphylococcus aureus Child Preschool Cyclosporine Female High incidence Brazil Cohort study Microbiology (medical) Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Adolescent 030106 microbiology Histamine Antagonists Dermatitis Atopic 03 medical and health sciences Internal medicine medicine Humans General Immunology and Microbiology business.industry SCCmec Infant Protective Factors S. aureus medicine.disease Methicillin-resistant Staphylococcus aureus Multivariate Analysis business |
| Zdroj: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 53(5), 724-730 Journal of Microbiology, Immunology and Infection, Vol 53, Iss 5, Pp 724-730 (2020) |
| ISSN: | 1684-1182 |
| Popis: | BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) colonization in Atopic Dermatitis (AD) patients can contribute to worsening their clinical condition.OBJECTIVE: A cohort study was carried out to determine the incidence of MRSA acquisition and its risk factors in AD children.METHODS: Patients with AD (2 months-14 years old) were followed up for about 1 year at a reference center for AD treatment in Rio de Janeiro, Brazil, from September 2011 to February 2014. Nasal swabs from patients and contacts were collected every 2 months. The SCORAD system assessed the severity of the AD. S. aureus isolates were evaluated to determine the methicillin resistance and the clonal lineages.RESULTS: Among 117 AD patients, 97 (82.9%) were already colonized with S. aureus and 26 (22.2%) had MRSA at the first evaluation. The incidence of MRSA acquisition in the cohort study was 27.47% (n = 25). The SCORAD assessments were: mild (46.15%), moderate (37.36%) or severe (16.48%). Risk factors were: colonized MRSA contacts (HR = 2.27; 95% CI: 1.16-7.54), use of cyclosporine (HR = 5.84; 95% CI: 1.70-19.98), moderate or severe AD (HR = 3.26; 95% CI: 1.13-9.37). Protective factors were: availability of running water (HR = 0.21; 95% CI: 0.049-0.96) and use of antihistamines (HR = 0.21; 95% IC: 0.64-0.75). MRSA isolates carried the SCCmec type IV and most of them were typed as USA800/ST5.CONCLUSIONS: The high incidence of MRSA acquisition found among AD patients and the risk factors associated show that an effective surveillance of MRSA colonization in these patients is needed. |
| Databáze: | OpenAIRE |
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