Different Gene Expression Signatures in Children and Adults with Celiac Disease
| Autor: | Miguel Fernández-Arquero, Andrés Bodas, Virginia Pascual, Natalia López-Palacios, Beatriz González-Pérez, Bárbara Dema, Isabel Salazar, Luz Maria Medrano, Concepción Núñez |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult CCR4 IL1RL1 Gene Expression lcsh:Medicine Disease Biology Pediatrics 03 medical and health sciences Families Gene expression Genetics Medicine and Health Sciences Ingestion Humans Adults Genetic Predisposition to Disease Gene Regulation Child lcsh:Science Gene Children Regulation of gene expression Multidisciplinary Gene Expression Profiling lcsh:R Biology and Life Sciences Human Genetics Human genetics Celiac Disease 030104 developmental biology Genetic Loci Age Groups Case-Control Studies Immunology People and Places Genetics of Disease Th17 Cells Population Groupings lcsh:Q Research Article |
| Zdroj: | PLoS ONE, Vol 11, Iss 2, p e0146276 (2016) PLoS ONE Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 1932-6203 |
| Popis: | Celiac disease (CD) is developed after gluten ingestion in genetically susceptible individuals. It can appear at any time in life, but some differences are commonly observed between individuals with onset early in life or in adulthood. We aimed to investigate the molecular basis underlying those differences. We collected 19 duodenal biopsies of children and adults with CD and compared the expression of 38 selected genes between each other and with the observed in 13 non-CD controls matched by age. A Bayesian methodology was used to analyze the differences of gene expression between groups. We found seven genes with a similarly altered expression in children and adults with CD when compared to controls (C2orf74, CCR6, FASLG, JAK2, IL23A, TAGAP and UBE2L3). Differences were observed in 13 genes: six genes being altered only in adults (IL1RL1, CD28, STAT3, TMEM187, VAMP3 and ZFP36L1) and two only in children (TNFSF18 and ICOSLG); and four genes showing a significantly higher alteration in adults (CCR4, IL6, IL18RAP and PLEK) and one in children (C1orf106). This is the first extensive study comparing gene expression in children and adults with CD. Differences in the expression level of several genes were found between groups, being notorious the higher alteration observed in adults. Further research is needed to evaluate the possible genetic influence underlying these changes and the specific functional consequences of the reported differences. |
| Databáze: | OpenAIRE |
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