Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial
| Autor: | Inez Trouwborst, Anouk Gijbels, Kelly M. Jardon, Els Siebelink, Gabby B. Hul, Lisa Wanders, Balázs Erdos, Szabolcs Péter, Cécile M. Singh-Povel, Johan de Vogel-van den Bosch, Michiel E. Adriaens, Ilja C.W. Arts, Dick H.J. Thijssen, Edith J.M. Feskens, Gijs H. Goossens, Lydia A. Afman, Ellen E. Blaak |
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| Přispěvatelé: | Humane Biologie, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: FSE MaCSBio, Maastricht Centre for Systems Biology, Epidemiologie |
| Rok vydání: | 2023 |
| Předmět: |
Physiology
tissue-specific insulin resistance Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Voeding Metabolisme en Genomica All institutes and research themes of the Radboud University Medical Center Voeding Humans Insulin glucose homeostasis Molecular Biology Diet Fat-Restricted precision nutrition VLAG Nutrition Global Nutrition Wereldvoeding Cell Biology Metabolism and Genomics metabotyping Phenotype Cardiovascular Diseases Metabolisme en Genomica Female Nutrition Metabolism and Genomics Insulin Resistance cardiometabolic health dietary intervention trial |
| Zdroj: | Cell Metabolism, 35, 1, pp. 71-83 Cell Metabolism 35 (2023) 1 Cell Metabolism, 35(1), 71-83.e5 Cell Metabolism, 35(1), 71-83.e5. Cell Press Cell Metabolism, 35, 71-83 |
| ISSN: | 1550-4131 |
| Popis: | Summary Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25–40 kg/m2, 40–75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17. |
| Databáze: | OpenAIRE |
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