Cardiovascular effects of intravenous vatinoxan in wild boars (Sus scrofa) anaesthetised with intramuscular medetomidine-tiletamine-zolazepam

Autor: Leith C. R. Meyer, Ulrike Auer, Joy Einwaller, Julia Nowack, Marja Raekallio, Anna Haw, Gabrielle Stalder, Johanna Painer, Sebastian G. Vetter
Přispěvatelé: Departments of Faculty of Veterinary Medicine, Equine and Small Animal Medicine, Helsinki One Health (HOH), DAPHNE - Developing Assessment Practices in Higher Education, Teachers' Academy, Marja Raekallio / Principal Investigator
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Cardiac output
NEAR-INFRARED SPECTROSCOPY
Swine
medicine.medical_treatment
Sus scrofa
medetomidine
413 Veterinary science
DEXMEDETOMIDINE-INDUCED SEDATION
0403 veterinary science
wild boar (Sus scrofa)
0302 clinical medicine
RECEPTOR ANTAGONIST
Heart Rate
030202 anesthesiology
Hypnotics and Sedatives
Saline
alpha-2-adrenergic agonists
Tiletamine
Cross-Over Studies
blood pressure
04 agricultural and veterinary sciences
General Medicine
ISOFLURANE
3. Good health
Anesthesia
ALPHA-2-ADRENOCEPTOR ANTAGONIST
PERIPHERAL ALPHA(2)-ADRENOCEPTOR ANTAGONIST
Quinolizines
medicine.drug
040301 veterinary sciences
03 medical and health sciences
Heart rate
medicine
Animals
BARORECEPTOR REFLEX
Pulmonary wedge pressure
COMBINATION
QL
General Veterinary
business.industry
Zolazepam
vatinoxan
Medetomidine
Blood pressure
pulmonary artery pressure
business
MK-467
CARDIOPULMONARY
ISSN: 0042-4900
Popis: Background The potent sedative medetomidine is a commonly used adjunct for the immobilisation of non-domestic mammals. However, its use is associated with pronounced cardiovascular side effects, such as bradycardia, vasoconstriction and decreased cardiac output. We investigated the effects of the peripherally-acting alpha-2-adrenoceptor antagonist vatinoxan on cardiovascular properties in medetomidine-tiletamine-zolazepam anaesthetised wild boar (Sus scrofa). Methods Twelve wild boars, anaesthetised twice with medetomidine (0.1 mg/kg) and tiletamine/zolazepam (2.5 mg/kg) IM in a randomised, crossover study, were administered (0.1 mg/kg) vatinoxan or an equivalent volume of saline IV (control). Cardiovascular variables, including heart rate (HR), mean arterial blood pressure (MAP), pulmonary artery pressure (PAP), pulmonary artery occlusion pressure (PAOP) and cardiac output (CO), were assessed 5 min prior to vatinoxan/saline administration until the end of anaesthesia 30 min later. Results MAP (p < 0.0001), MPAP (p < 0.001) and MPAOP (p < 0.0001) significantly decreased from baseline after vatinoxan until the end of anaesthesia. HR increased significantly (p < 0.0001) from baseline after vatinoxan administration. However, the effect on HR subsided 3 min after vatinoxan. All variables remained constant after saline injection. There was no significant effect of vatinoxan or saline on CO. Conclusion Vatinoxan significantly reduced systemic and pulmonary artery hypertension, induced by medetomidine in wild boar.
Databáze: OpenAIRE
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