Tumour Budding and Survival in Stage II Colorectal Cancer: a Systematic Review and Pooled Analysis
| Autor: | Veronica Lonati, Mara Ghilardi, Sandro Barni, Ezio Pezzica, A. Coinu, D. Corti, Fausto Petrelli, Mary Cabiddu, Karen Borgonovo |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Male medicine.medical_specialty business.industry Colorectal cancer medicine.medical_treatment Hazard ratio Gastroenterology Odds ratio medicine.disease Prognosis Survival Analysis Confidence interval Radiation therapy Tumor budding Internal medicine Meta-analysis Medicine Humans Female business Colorectal Neoplasms Survival analysis Neoplasm Staging |
| Zdroj: | Journal of gastrointestinal cancer. 46(3) |
| ISSN: | 1941-6636 |
| Popis: | Tumour budding is defined as the presence of isolated or small clusters of malignant cells at the invasive edge of the tumour. It is considered a negative prognostic factor in colorectal cancer (CRC) and is associated with a poor outcome and adverse pathological features. Here, we report a meta-analysis of the association of tumour budding and survival in stage II CRC patients. PubMed, EMBASE, Web of Science and SCOPUS were searched for studies that assessed the relationship between tumour budding and 5-year overall survival (OS) in stage II CRC patients. Published data were extracted and used to compute odds ratios (ORs) for death at 5 years and hazard ratios (HRs) for survival amongst patients with respect to the extent of tumour budding, using multivariate analysis. Data were pooled using the Mantel–Haenszel random effect model. We analysed 12 studies that included a total of 1652 patients. High-grade budding was associated with worse OS at 5 years (OR for death, 6.25; 95 % confidence interval [CI], 4.04–9.67; P |
| Databáze: | OpenAIRE |
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