Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria
| Autor: | Christiane Chbib |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Gram-negative bacteria
medicine.drug_class Clinical Biochemistry Antibiotics Molecular Conformation Pharmaceutical Science Microbial Sensitivity Tests Acyl-Butyrolactones Biochemistry Microbiology Structure-Activity Relationship Microbial resistance Drug Discovery Gram-Negative Bacteria medicine Structure–activity relationship Animals Humans Molecular Biology biology Chemistry Organic Chemistry Quorum Sensing Biological activity biology.organism_classification Anti-Bacterial Agents Quorum sensing Molecular Medicine Autoinducer |
| Zdroj: | Bioorganicmedicinal chemistry. 28(3) |
| ISSN: | 1464-3391 |
| Popis: | With the emergence of microbial resistance pathogens, recent research aims at studying new mechanisms of action of antibiotics. This review discusses the mechanisms and types of quorum sensing (QS) inhibitors in Gram negative bacteria. It illustrates all published data available in literature pertaining to novel compounds that showed activity against different targets in the quorum sensing pathways in Gram negative bacteria. A systemic overview has been conducted by searching PubMed, Medline, and the Cochrane Library and data extraction of all quorum sensing inhibitors with their mechanisms of action have been collected. This review will focus on signaling autoinducer AI-1 in Gram negative bacteria. The biological activity of the antagonists is mainly reported as IC50 (the concentration of an inhibitor where the response is reduced by half). |
| Databáze: | OpenAIRE |
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